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Crosslinking Between Trichocyte Keratins and Keratin Associated Proteins

  • Santanu Deb-Choudhury
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1054)

Abstract

Trichocyte keratins differ considerably from their epithelial cousins in having a higher number of cysteine residues, of which the greater proportion are located in the head and tail regions of these proteins. Coupled with this is the presence of a large number of keratin associated proteins in these fibres that are high in their cysteine content, the high sulfur proteins and ultra-high sulfur proteins. Thus it is the crosslinking that occurs between the cysteines in the keratins and KAPs that is an important determinant in the functionality of wool and hair fibres. Studies have shown the majority of the cysteine residues are involved in internal crosslinking in the KAPs leaving only a few specific cysteines to interact with the keratins, with most evidence pointing to interactions between these KAP cysteines and the keratin head groups.

Keywords

Trichocyte keratins Keratin associated proteins Protein crosslinks Disulfide bridges Cysteine accessibility 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.AgResearch Ltd.LincolnNew Zealand

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