Endophytic Microbes as a Novel Source for Producing Anticancer Compounds as Multidrug Resistance Modulators

  • Julio Alves Cardoso FilhoEmail author


Endophytes are a range of microorganisms which inhabit the plant tissues, establishing an association with their hosts during a period for nearly or all their life without causing any apparent damage. It is known that some of these microorganisms have the potential to produce a diverse range of molecules that may be a reservoir of pharmaceutical drugs with anticancer activity. Cancer is a major trouble public health in all countries of the world, and this disease has higher mortality rate. Cancer is a name given to a complex disease, which is distinguished by the development and expansion of untypical cells and can lead to death. Nowadays the multidrug resistance (MDR) in cancer chemotherapy, remains a challenge to human and animal health around the world, which in several cases makes treatment inefficient. As a result, an increased number of strategies have been encouraged in search of MDR modulators (drugs that overcome MDR capacity) from various natural resources including endophyte-derived compounds. Thus, the aim of this chapter is to present the current status of several strategies adopted to promote the identification of some of these bioactive endophyte-derived compounds such as flavonoids, coumarins, polysaccharides, and β-glucans and to demonstrate their pharmaceutical potential as MDR modulators.


Chemotherapy Cytotoxicity Plant-microbe interaction Secondary metabolites Therapeutic drugs 



We thank the editors and the all anonymous reviewers for their constructive comments, which helped us to improve this chapter.

Conflict of Interest

The author certifies that there is no conflict of interest with any financial organization regarding the material discussed in this chapter.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Centre of Agricultural Sciences, Sector of Plant PathologyFederal University of AlagoasRio LargoBrazil

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