Remedy of Targeting Cancer and Cancer Stem Cells with Botanicals

  • Rajanna AjumeeraEmail author
  • Ganapathi Thipparapu
  • Suresh Challa


The cancer disease burden is increasing regularly due to various factors like mutation occurrence in genes, environmental changes, adopting a modern lifestyle, less physical exercises, and modern food habits. To cure this disease, chemotherapy is the major option including surgery for solid tumors followed by radiation therapy. Chemotherapy is associated with lots of side effects with synthetic compounds, whereas natural source of plant extracts and products is reliable and has less side effects of treatment. In line with this, plant extracts with active ingredients having anticancer potential are becoming popular for cancer therapy. These plant extracts are associated with more than one active compound. But, extraction procedures to convert them into final drug products are associated with different hurdles. However, recent research advocates that the real culprit of the disease is cancer stem cells present in tumor. There is a need to target cancer stem cells to bring novel strategies for the therapy. The present chapter summarizes the anticancer activities of plant active components targeting cancer as well as cancer stem cells for therapeutics.


Cancer stems cells MDR Phytochemicals Signaling Therapy 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Rajanna Ajumeera
    • 1
    Email author
  • Ganapathi Thipparapu
    • 1
  • Suresh Challa
    • 1
  1. 1.Stem Cell Research Division, Department of BiochemistryNational Institute of Nutrition, Indian Council of Medical ResearchHyderabadIndia

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