Tumors of the Skin

  • Yong-Hang Zhu
  • Gui-Xiu Zhang
  • Li Tang
  • Xiao-Jie Li
  • Wen-Yuan Zhu
  • Ru-Zhi Zhang
  • Ming-Yu Xia
  • Lei Wang
  • Ying Ren
  • Hui-Pu Zhou
  • De-Hai Pan
  • Li-Jian Xiang
  • Jin-Fa Su
  • Hui Zhang
  • Juan Du
  • Mai-Hua Hou
  • Dong-Lai Ma
  • Shu-Qin Lv
  • Xi-Chuan Yang
  • Jie Gao
  • Ting Lin
  • Shao-Wen Peng
  • Zhi-Ping Sun
  • Li Yang
  • Cheng TanEmail author
  • Ji-Ling Zhang
  • Yan Wu
  • Hong Zhang
  • Gang Liu
  • Bao-Chun Li
  • Shun-Fan Li
  • Lan Yang
  • Jie Yan
  • Yang Guan
  • Yin Xiao
  • Yan Yan
  • Zhi-Fang Zhai
  • Shan Tang
  • Zhong Xie
  • Feng Wu
  • Xiao-Mei Zhang
  • Jian-Fang Sun
  • Wen-Hai Li
  • Mei Cai
  • Chun-Mei Zhang
  • Xian Zhang
  • Gang Wang
  • Hong-Hao Jiang
  • Jiang Jin
  • Xiong-Ming Pu
  • Jian-Min Chang
  • Yan Lu
  • Xiao-Jun Zhu
  • Cun-Cai Zhou
  • Shu-Fang Qiao
  • Jian-Ping Liang
  • Zhi-Xin Song
  • Yi-Ming Xu
  • Jun Peng
  • Hong-Zhong Jin
  • Chun-Xing Xu
  • Jing Fang
  • Chuan-Ping Xing
  • Xiao-Bing Pi
  • Dian-Ying Zhuang
  • Jia-Bi Wang
  • Jian-Ying Zeng
  • Min Huang
  • Chun-Yang Li
  • Bing-Nan Cui
  • Xiao-Yan Guo
  • Tong Lin
  • Bing-Sen Qiu
  • Bin Su
  • Xue-Jun Zhu
  • Pei-Hua Song
  • Guang-Cai Xiang
  • Guang-Ren Liu
  • Sheng-Shun Tan
  • Yi-Qun Jiang
  • Min Zheng
  • Jin Hu
  • Guang-He Yang
  • Zheng Ge
  • Jing Chen
  • Lin Cai
  • Sheng Wang
  • An Liu
  • Xian Jiang


Skin tumor is the most intriguing topic for the clinicians. This chapter covers a wide range of issues and provides with informative clues and tips associated with clinical features and pathological presentations and keeps pace with the latest development in molecular biology and immunohistochemistry to assist the readers in the establishment of accurate diagnosis. These following disorders are elaborately selected and arranged from a histopathological perspective.

(1) Tumors of the epidermis include epidermal nevus, unilateral epidermal nevus, epidermal nevus syndrome, seborrheic keratosis, seborrheic keratosis and pityrosporum ovale, large cell acanthoma, giant cutaneous horn, multiple Bowen’s disease, extramammary Paget’s disease, eruptive keratoacanthoma, superficial basal cell carcinoma, fibroepithelioma of Pinkus, Marjolin’s ulcer of squamous cell carcinoma secondary to radiation, cutaneous clear cell squamous cell carcinoma, and milia en plaque.

(2) The list of cutaneous appendage proliferations and tumors present cases with eruptive vellus hair cysts, nevus comedonicus, dilated pore, inverted follicular keratosis, infundibulocystic basal cell carcinoma, trichofolliculoma, trichoepithelioma, bullous pilomatricoma, areolar sebaceous hyperplasia, nevus sebaceous with apocrine cystadenoma, linear nevus sebaceous syndrome, apocrine hidrocystoma, eccrine angiomatous hamartoma, syringocystadenoma papilliferum, eruptive milium-like syringoma, segmental multiple eccrine spiradenomas, clear cell hidradenoma, malignant eccrine poroma, or microcystic adnexal carcinoma.

(3) The category of cutaneous soft tissue proliferations and neoplasms introduces acquired digital fibrokeratoma, epithelioid cell histiocytoma, multiple eruptive dermatofibromas, intradermal nodular fasciitis, dermatofibrosarcoma protuberan, epithelioid sarcoma, superficial angiomyxoma, multicentric reticulohistiocytosis, Letterer-Siwe disease, cutaneous Rosai-Dorfman disease, phakomatosis pigmentovascularis, angiokeratoma corporis diffusum, angiokeratoma of Fordyce, angioma serpiginosum, reactive angioendotheliomatosis, epithelioid hemangioma, tufted angioma, verrucous hemangioma, targetoid hemosiderotic hemangioma, microvenular hemangioma, glomus tumor, spindle cell hemangioma, Kaposiform hemangioendothelioma, classic Kaposi’s sarcoma, cutaneous angiosarcoma, acquired progressive lymphangioma, lymphangioma, nevus lipomatosus superficialis, encephalocraniocutaneous lipomatosis, madelung disease, multiple leiomyoma, cutaneous leiomyosarcoma, subungual exostosis, and cutaneous endometriosis.

(4) Palisaded encapsulated neuroma, schwannoma, and cutaneous Merkel cell carcinoma belong to neural tumors.

(5) Melanocytic nevi and neoplasms include agminated Spitz nevus, subungual melanoma, fatal leptomeningeal melanoma in neurocutaneous melanosis, as well as rare forms of cutaneous melanoma.

(6) Cutaneous lymphoid proliferations and leukemic infiltration consist of cutaneous pseudolymphoma, Jessner’s lymphocytic infiltration of the skin Jessner, Ketron-Goodman disease, mycosis fungoides, erythrodermic cutaneous T-cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma, hydroa vacciniforme-like lymphoma, extranodal NK-/T-cell lymphoma, primary cutaneous B-cell lymphoma, maculopapular cutaneous mastocytosis, diffuse cutaneous mastocytosis, mastocytoma, cutaneous plasmacytoma, polycythemia vera, leukemia cutis, and so on.

(7) Cutaneous metastases include cutaneous metastasis for lung cancer, cutaneous metastasis of gastrointestinal malignancy, Sister Mary Joseph’s nodule, and carcinoma en cuirasse.


  1. 1.
    Curth HO. Unilateral epidermal naevus resembling acanthosis nigricans. Br J Dermatol. 1976;95(4):433–6.CrossRefPubMedGoogle Scholar
  2. 2.
    Khachemoune A, Janjua SA, Guldbakke KK. Inflammatory linear verrucous epidermal nevus: a case report and short review of the literature. Cutis. 2006;78(4):261–7.PubMedGoogle Scholar
  3. 3.
    Zheng LQ, Huang Y, Qu YJ, Zhang YH, Han XC. Multiple basal cell carcinomas arising in a verrucous epidermal nevus. J Dermatol. 2013;40(6):482–3. Scholar
  4. 4.
    Demetree JW, Lang PG, St Clair JT. Unilateral, linear, zosteriform epidermal nevus with acantholytic dyskeratosis. Arch Dermatol. 1979;115(7):875–7.CrossRefPubMedGoogle Scholar
  5. 5.
    Ozcelik D, Parlak AH, Ozturk A, Kavak A, Celikel N. Unilateral linear verrucous epidermal nevus of the face and the oral mucosa. Plast Reconstr Surg. 2005;115(2):17e–9e.CrossRefPubMedGoogle Scholar
  6. 6.
    Laura FS. Epidermal nevus syndrome. Handb Clin Neurol. 2013;111:349–68. Scholar
  7. 7.
    Vujevich JJ, Mancini AJ. The epidermal nevus syndromes: multisystem disorders. J Am Acad Dermatol. 2004;50(6):957–61.CrossRefPubMedGoogle Scholar
  8. 8.
    Goldberg LH, Collins SA, Siegel DM. The epidermal nevus syndrome: case report and review. Pediatr Dermatol. 1987;4(1):27–33.CrossRefPubMedGoogle Scholar
  9. 9.
    Zhu WY. Multiple small papular seborrheic keratosis. Chin Med J. 1988;101(7):490–2.PubMedGoogle Scholar
  10. 10.
    Li X, Zhu W. A case of seborrheic keratosis distributed along skin cleavage lines. J Dermatol. 1998;25(4):272–4.CrossRefPubMedGoogle Scholar
  11. 11.
    Hafner C, Vogt T. Seborrheic keratosis. J Dtsch Dermatol Ges. 2008;6(8):664–77. Scholar
  12. 12.
    Bourlond A, Votion V, Armijo F, Minne G. Pityrosporum ovale in keratotic lesions of seborrheic areas. Ann Dermatol Venereol. 1984;111(12):1081–5.PubMedGoogle Scholar
  13. 13.
    Sanchez Yus E, del Rio E, Requena L. Large-cell acanthoma is a distinctive condition. Am J Dermatopathol. 1992;14(2):140–7. discussion 148CrossRefPubMedGoogle Scholar
  14. 14.
    Mehregan DR, Hamzavi F, Brown K. Large cell acanthoma. Int J Dermatol. 2003;42(1):36–9.CrossRefPubMedGoogle Scholar
  15. 15.
    Yoon YH, Ju HJ, Lee KH, Park CJ. A cutaneous horn-like form of juvenile xanthogranuloma. Ann Dermatol. 2016;28(6):783–4. Scholar
  16. 16.
    Mantese SA, Diogo PM, Rocha A, Berbert AL, Ferreira AK, Ferreira TC. Cutaneous horn: a retrospective histopathological study of 222 cases. An Bras Dermatol. 2010;85(2):157–63.CrossRefPubMedGoogle Scholar
  17. 17.
    Morton CA, Whitehurst C, McColl JH, Moore JV, MacKie RM. Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma. Arch Dermatol. 2001;137(3):319–24.PubMedGoogle Scholar
  18. 18.
    Murao K, Nakasuka A, Keyama T, Hashimoto I, Kubo Y. Case of multiple Bowen diseases associated with human papillomavirus type 16 in a patient with atopic dermatitis. J Dermatol. 2016;43(4):445–7. Scholar
  19. 19.
    Kuniyuki S, Maekawa N. Ectopic extramammary Paget’s disease on the head: case report and literature review. Int J Dermatol. 2015;54(11):e483–6. Scholar
  20. 20.
    Lloyd J, Flanagan AM. Mammary and extramammary Paget’s disease. J Clin Pathol. 2000;53(10):742–9.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Kwiek B, Schwartz RA. Keratoacanthoma (KA): an update and review. J Am Acad Dermatol. 2016;74(6):1220–33. Scholar
  22. 22.
    Nofal A, Assaf M, Ghonemy S, Nofal E, Yosef A. Generalized eruptive keratoacanthoma: a diagnostic and therapeutic challenge. Int J Dermatol. 2015;54(2):160–7. Scholar
  23. 23.
    Schwartz RA. Keratoacanthoma: a clinico-pathologic enigma. Dermatol Surg. 2004;30(2 Pt 2):326–33. discussion 333PubMedPubMedCentralGoogle Scholar
  24. 24.
    Handa Y, Kato Y, Ishikawa H, Tomita Y. Giant superficial basal cell carcinoma of the scrotum. Eur J Dermatol. 2005;15(3):186–8.PubMedGoogle Scholar
  25. 25.
    Pyne JH, Myint E, Barr EM, Clark SP, David M, Na R, Hou R. Superficial basal cell carcinoma: a comparison of superficial only subtype with superficial combined with other subtypes by age, sex and anatomic site in 3150 cases. J Cutan Pathol. 2017;44:677–83. Scholar
  26. 26.
    Katona TM, Ravis SM, Perkins SM, Moores WB, Billings SD. Expression of androgen receptor by fibroepithelioma of Pinkus: evidence supporting classification as a basal cell carcinoma variant? Am J Dermatopathol. 2007;29(1):7–12. Scholar
  27. 27.
    Park MY, Kim YC. Fibroepithelioma of Pinkus: poor response to topical photodynamic therapy. Eur J Dermatol. 2010;20(1):133–4. Scholar
  28. 28.
    Pavlovic S, Wiley E, Guzman G, Morris D, Braniecki M. Marjolin ulcer: an overlooked entity. Int Wound J. 2011;8(4):419–24. Scholar
  29. 29.
    Reich-Schupke S, Doerler M, Wollina U, Dissemond J, Horn T, Strolin A, Erfurt-Berge C, Stucker M. Squamous cell carcinomas in chronic venous leg ulcers. Data of the German Marjolin Registry and review. J Dtsch Dermatol Ges. 2015;13(10):1006–13. Scholar
  30. 30.
    Al-Arashi MY, Byers HR. Cutaneous clear cell squamous cell carcinoma in situ: clinical, histological and immunohistochemical characterization. J Cutan Pathol. 2007;34(3):226–33. Scholar
  31. 31.
    Misago N, Toda S, Narisawa Y. Tricholemmoma and clear cell squamous cell carcinoma (associated with Bowen’s disease): immunohistochemical profile in comparison to normal hair follicles. Am J Dermatopathol. 2012;34(4):394–9. Scholar
  32. 32.
    Barzegar M, Mozafari N. A new site of milia en plaque: report of a case and review of the literature. Int J Dermatol. 2015;54(12):1423–5. Scholar
  33. 33.
    Ergin S, Basak P, Sari A. Milia en plaque. J Eur Acad Dermatol Venereol. 2000;14(1):47–9.CrossRefPubMedGoogle Scholar
  34. 34.
    Martins LE, Werner B, Fonseca GP. Milia en plaque. An Bras Dermatol. 2010;85(6):895–8.CrossRefPubMedGoogle Scholar
  35. 35.
    Torchia D, Vega J, Schachner LA. Eruptive vellus hair cysts: a systematic review. Am J Clin Dermatol. 2012;13(1):19–28. Scholar
  36. 36.
    Shi G, Zhou Y, Cai YX, Li SJ, Fan YM. Clinicopathological features and expression of four keratins (K10, K14, K17 and K19) in six cases of eruptive vellus hair cysts. Clin Exp Dermatol. 2014;39(4):496–9. Scholar
  37. 37.
    Hong SD, Frieden IJ. Diagnosing eruptive vellus hair cysts. Pediatr Dermatol. 2001;18(3):258–9.CrossRefPubMedGoogle Scholar
  38. 38.
    Tchernev G, Ananiev J, Semkova K, Dourmishev LA, Schonlebe J, Wollina U. Nevus comedonicus: an updated review. Dermatol Ther (Heidelb). 2013;3(1):33–40. Scholar
  39. 39.
    Ferrari B, Taliercio V, Restrepo P, Luna P, Abad ME, Larralde M. Nevus comedonicus: a case series. Pediatr Dermatol. 2015;32(2):216–9. Scholar
  40. 40.
    Moreira A, Menezes N, Guedes R, Tente D, Baptista A, Varela P. Dermoscopy of a dilated pore of Winer. Eur J Dermatol. 2010;20(2):229. Scholar
  41. 41.
    Resnik KS, Kantor GR, Howe NR, Ditre CM. Dilated pore nevus. A histologic variant of nevus comedonicus. Am J Dermatopathol. 1993;15(2):169–71.CrossRefPubMedGoogle Scholar
  42. 42.
    Llambrich A, Zaballos P, Taberner R, Terrasa F, Banuls J, Pizarro A, Malvehy J, Puig S. Dermoscopy of inverted follicular keratosis: study of 12 cases. Clin Exp Dermatol. 2016;41(5):468–73. Scholar
  43. 43.
    Mehregan AH. Inverted follicular keratosis is a distinct follicular tumor. Am J Dermatopathol. 1983;5(5):467–70.CrossRefPubMedGoogle Scholar
  44. 44.
    Honarpisheh H, Glusac EJ, Ko CJ. Cytokeratin 20 expression in basaloid follicular hamartoma and infundibulocystic basal cell carcinoma. J Cutan Pathol. 2014;41(12):916–21. Scholar
  45. 45.
    Kato N, Ueno H. Infundibulocystic basal cell carcinoma. Am J Dermatopathol. 1993;15(3):265–7.CrossRefPubMedGoogle Scholar
  46. 46.
    Romero-Perez D, Garcia-Bustinduy M, Cribier B. Clinicopathologic study of 90 cases of trichofolliculoma. J Eur Acad Dermatol Venereol. 2017;31(3):e141–2. Scholar
  47. 47.
    Kallam AR, Satyanarayana MA, Aryasomayajula S, Krishna BA. Basal cell carcinoma developing from trichoepithelioma: review of three cases. J Clin Diagn Res. 2016;10(3):PD17–9. Scholar
  48. 48.
    Liang YH, Gao M, Sun LD, Liu LJ, Cui Y, Yang S, Fan X, Wang J, Xiao FL, Zhang XJ. Two novel CYLD gene mutations in Chinese families with trichoepithelioma and a literature review of 16 families with trichoepithelioma reported in China. Br J Dermatol. 2005;153(6):1213–5. Scholar
  49. 49.
    Parren LJ, Munte K, Winnepenninckx V, van Geel M, Steijlen PM, Frank J, van Steensel MA. Clustered unilateral trichoepitheliomas indicate Type 1 segmental manifestation of multiple familial trichoepithelioma. Clin Exp Dermatol. 2016;41(6):682–4. Scholar
  50. 50.
    Fetil E, Soyal MC, Menderes A, Lebe B, Gunes AT, Ozkan S. Bullous appearance of pilomatricoma. Dermatol Surg. 2003;29(10):1066–7.PubMedGoogle Scholar
  51. 51.
    Ozkaya DB, Su O, Taskin B, Tas B, Sar M, Onsun N. Bullous pilomatricoma. Eur J Dermatol. 2013;23(1):104–5. Scholar
  52. 52.
    Belinchon I, Aguilar A, Tardio J, Gallego MA. Areolar sebaceous hyperplasia: a case report. Cutis. 1996;58(1):63–4.PubMedGoogle Scholar
  53. 53.
    Chiriac A, Moldovan C, Coros MF, Podoleanu C, Moncea D, Stolnicu S. Bilateral areolar sebaceous hyperplasia in a post-menopausal woman. Eur J Dermatol. 2016;26(3):299–300. Scholar
  54. 54.
    Tsuji T, Yamauchi R. Areolar sebaceous hyperplasia with a Fordyce’s spot-like lesion. J Dermatol. 1994;21(7):524–6.CrossRefPubMedGoogle Scholar
  55. 55.
    Campbell JP, Solomon AR Jr, Woo TY. Apocrine cystadenoma arising in a nevus sebaceus of Jadassohn. Cutis. 1984;34(5):510–2.PubMedGoogle Scholar
  56. 56.
    Kamyab-Hesari K, Seirafi H, Jahan S, Aghazadeh N, Hejazi P, Azizpour A, Goodarzi A. Nevus sebaceus: a clinicopathological study of 168 cases and review of the literature. Int J Dermatol. 2016;55(2):193–200. Scholar
  57. 57.
    Hsu MC, Liau JY, Hong JL, Cheng Y, Liao YH, Chen JS, Sheen YS, Hong JB. Secondary neoplasms arising from nevus sebaceus: a retrospective study of 450 cases in Taiwan. J Dermatol. 2016;43(2):175–80. Scholar
  58. 58.
    Lovejoy FH Jr, Boyle WE Jr. Linear nevus sebaceous syndrome: report of two cases and a review of the literature. Pediatrics. 1973;52(3):382–7.PubMedGoogle Scholar
  59. 59.
    Menascu S, Donner EJ. Linear nevus sebaceous syndrome: case reports and review of the literature. Pediatr Neurol. 2008;38(3):207–10. Scholar
  60. 60.
    Gilchrist HM, Wick MR, Patterson JW. Liesegang rings in an apocrine hidrocystoma: a case report and review of literature. J Cutan Pathol. 2010;37(10):1064–6. Scholar
  61. 61.
    Lopez V, Alonso V, Jorda E, Santonja N. Apocrine hidrocystoma on the penis of a 40-year-old man. Int J Dermatol. 2013;52(4):502–4. Scholar
  62. 62.
    Holcomb M, Sun G, Eldin K, Brandon K. Verrucous hyperpigmented plaque in a 15-month-old boy. Eccrine angiomatous hamartoma (EAH) associated with verrucous hemangioma (VH). Int J Dermatol. 2013;52(1):25–6. Scholar
  63. 63.
    Patterson AT, Kumar MG, Bayliss SJ, Witman PM, Dehner LP, Gru AA. Eccrine angiomatous hamartoma: a clinicopathologic review of 18 cases. Am J Dermatopathol. 2016;38(6):413–7. Scholar
  64. 64.
    Dufrechou L, Acosta A, Beltramo P, Pomies V, Caruso R, Salmenton GM, Alvarez M. Syringocystadenoma papilliferum arising on the scrotum. Pediatr Dermatol. 2013;30(3):e12–3. Scholar
  65. 65.
    Kasashima S, Kawashima A, Fujii T. Syringocystadenoma papilliferum of the male nipple. J Cutan Pathol. 2016;43(8):679–83. Scholar
  66. 66.
    Philipone E, Chen S. Unique case: syringocystadenoma papilliferum associated with an eccrine nevus. Am J Dermatopathol. 2009;31(8):806–7. Scholar
  67. 67.
    Tatsuno K, Yagi H, Tokura Y. Eruptive milium-like syringoma showing eccrine duct origin of milia. J Dermatol. 2012;39(10):878–9. Scholar
  68. 68.
    Zhong P, Tan C. Dermoscopic features of eruptive milium-like syringoma. Eur J Dermatol. 2015;25(2):203–4. Scholar
  69. 69.
    Ren F, Hu Z, Kong Q, Sang H. Multiple segmental eccrine spiradenoma with a zosteriform pattern: a case report and literature review. Ann Dermatol. 2015;27(4):435–8. Scholar
  70. 70.
    Rodriguez-Martin M, Sanchez Gonzalez R, Saez-Rodriguez M, Garcia-Bustinduy M, Martin-Herrera A, Noda-Cabrera A. An unusual case of congenital linear eccrine spiradenoma. Pediatr Dermatol. 2009;26(2):180–3. Scholar
  71. 71.
    Yoshida A, Sato T, Sugawara Y, Matsuta M, Akasaka T. Two cases of multiple eccrine spiradenoma with linear or localized formation. J Dermatol. 2004;31(7):564–8.CrossRefPubMedGoogle Scholar
  72. 72.
    Au B, Sidiropoulos KG, Ghazarian D, Sidiropoulos M. Lymph node involvement by a clear cell nodular hidradenoma-like tumor of uncertain malignant potential. Am J Dermatopathol. 2017;39:953–4. Scholar
  73. 73.
    Gilaberte Y, Grasa MP, Carapeto FJ. Clear cell hidradenoma. J Am Acad Dermatol. 2006;54(5 Suppl):248–9. Scholar
  74. 74.
    Yu G, Goodloe S Jr, D’Angelis CA, McGrath BE, Chen F. Giant clear cell hidradenoma of the knee. J Cutan Pathol. 2010;37(9):e37–41. Scholar
  75. 75.
    Pena J, Suster S. Squamous differentiation in malignant eccrine poroma. Am J Dermatopathol. 1993;15(5):492–6.CrossRefPubMedGoogle Scholar
  76. 76.
    Perna C, Cuevas J, Jimenez-Heffernan JA, Hardisson D, Contreras F. Eccrine porocarcinoma (malignant eccrine poroma). Am J Surg Pathol. 2002;26(2):272–4.CrossRefPubMedGoogle Scholar
  77. 77.
    Sawaya JL, Khachemoune A. Poroma: a review of eccrine, apocrine, and malignant forms. Int J Dermatol. 2014;53(9):1053–61. Scholar
  78. 78.
    Chen J, Yang S, Chen J, Liao T, Deng W, Li W. Microcystic adnexal carcinoma in a non-Caucasian patient: a case report and review of the literature. Oncol Lett. 2016;11(4):2471–4. Scholar
  79. 79.
    Jfri A, Al Hawsawi K, Marghalani S, Alkhuzaie A. Microcystic adnexal carcinoma: unusual presentation. J Eur Acad Dermatol Venereol. 2016;30(1):165–7. Scholar
  80. 80.
    McKinley LH, Seastrom S, Hanly AJ, Miller RA. Microcystic adnexal carcinoma: review of a potential diagnostic pitfall and management. Cutis. 2014;93(3):162–5.PubMedGoogle Scholar
  81. 81.
    Baykal C, Buyukbabani N, Yazganoglu KD, Saglik E. Acquired digital fibrokeratoma. Cutis. 2007;79(2):129–32.PubMedGoogle Scholar
  82. 82.
    Berger RS, Spielvogel RL. Dermal papule on a distal digit. Acquired digital fibrokeratoma. Arch Dermatol. 1988;124(10):1559–60. 1562–3CrossRefPubMedGoogle Scholar
  83. 83.
    Jang MS, Kang DY, Park JB, Kang JS, Baek JW, Kim ST, Suh KS. Epithelioid cell histiocytoma: broad differential diagnostic considerations. J Dermatol. 2012;39(6):579–81. Scholar
  84. 84.
    Manente L, Schmitt I, Onetti AM, Peris K, Caracciolo E, Chimenti S. Cutaneous epithelioid cell histiocytoma: immunohistochemical and ultrastructural findings suggesting endothelial origin. Am J Dermatopathol. 1997;19(5):519–23.CrossRefPubMedGoogle Scholar
  85. 85.
    Mehregan AH, Mehregan DR, Broecker A. Epithelioid cell histiocytoma. A clinicopathologic and immunohistochemical study of eight cases. J Am Acad Dermatol. 1992;26(2 Pt 1):243–6.CrossRefPubMedGoogle Scholar
  86. 86.
    Alexandrescu DT, Wiernik PH. Multiple eruptive dermatofibromas occurring in a patient with chronic myelogenous leukemia. Arch Dermatol. 2005;141(3):397–8. Scholar
  87. 87.
    Llamas-Velasco M, Fraga J, Solano-Lopez GE, Steegmann JL, Garcia Diez A, Requena L. Multiple eruptive dermatofibromas related to imatinib treatment. J Eur Acad Dermatol Venereol. 2014;28(7):979–81. Scholar
  88. 88.
    Veraldi S, Bocor M, Gianotti R, Gasparini G. Multiple eruptive dermatofibromas localized exclusively to the buttock. Int J Dermatol. 1991;30(7):507–8.CrossRefPubMedGoogle Scholar
  89. 89.
    de Feraudy S, Fletcher CD. Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases. Am J Surg Pathol. 2010;34(9):1377–81. Scholar
  90. 90.
    Terai M, Oka M, Kunisada M, Kawakami F, Nishigori C. Intradermal nodular fasciitis. Eur J Dermatol. 2012;22(2):285–6. Scholar
  91. 91.
    Buck DW 2nd, Kim JY, Alam M, Rawlani V, Johnson S, Connor CM, Dumanian GA, Wayne JD. Multidisciplinary approach to the management of dermatofibrosarcoma protuberans. J Am Acad Dermatol. 2012;67(5):861–6. Scholar
  92. 92.
    Kuzel P, Mahmood MN, Metelitsa AI, Salopek TG. A clinicopathologic review of a case series of dermatofibrosarcoma protuberans with fibrosarcomatous differentiation. J Cutan Med Surg. 2015;19(1):28–34. Scholar
  93. 93.
    Thway K, Noujaim J, Jones RL, Fisher C. Dermatofibrosarcoma protuberans: pathology, genetics, and potential therapeutic strategies. Ann Diagn Pathol. 2016;25:64–71. Scholar
  94. 94.
    Halling AC, Wollan PC, Pritchard DJ, Vlasak R, Nascimento AG. Epithelioid sarcoma: a clinicopathologic review of 55 cases. Mayo Clin Proc. 1996;71(7):636–42. Scholar
  95. 95.
    Jamshidi F, Bashashati A, Shumansky K, Dickson B, Gokgoz N, Wunder JS, Andrulis IL, Lazar AJ, Shah SP, Huntsman DG, Nielsen TO. The genomic landscape of epithelioid sarcoma cell lines and tumours. J Pathol. 2016;238(1):63–73. Scholar
  96. 96.
    Sobanko JF, Meijer L, Nigra TP. Epithelioid sarcoma: a review and update. J Clin Aesthet Dermatol. 2009;2(5):49–54.PubMedPubMedCentralGoogle Scholar
  97. 97.
    Basak S, Rogers S, Solomonsz AF. Superficial angiomyxoma of the vulva: a case report of a rare cutaneous tumour. J Obstet Gynaecol. 2011;31(4):360–1. Scholar
  98. 98.
    Falidas E, Rallis E, Vlachos C, Konstantoudakis S, Villias C. Superficial subungual angiomyxoma: case report and review of the literature. J Cutan Med Surg. 2011;15(3):180–2. Scholar
  99. 99.
    Cyrulnik AA, Paz KB, Amin B, Mann RE, Krishnamurthy K, Friedman AJ. Multicentric reticulohistiocytosis: contrasting presentations in 2 Hispanic patients. Cutis. 2014;93(5):243–6.PubMedGoogle Scholar
  100. 100.
    Kandiah DA. Multicentric reticulohistiocytosis. Mayo Clin Proc. 2014;89(8):e73. Scholar
  101. 101.
    Selmi C, Greenspan A, Huntley A, Gershwin ME. Multicentric reticulohistiocytosis: a critical review. Curr Rheumatol Rep. 2015;17(6):511. Scholar
  102. 102.
    Tajirian AL, Malik MK, Robinson-Bostom L, Lally EV. Multicentric reticulohistiocytosis. Clin Dermatol. 2006;24(6):486–92. Scholar
  103. 103.
    Kuttner BJ, Friedman KJ, Burton CS 3rd, Olsen EA. Letterer-Siwe disease in an adult. Cutis. 1987;39(2):142–6.PubMedGoogle Scholar
  104. 104.
    Wright AL, Tucker WF, Slater DN, Harrington CI. Letterer-Siwe disease in the ninth decade. J Am Acad Dermatol. 1985;12(2 Pt 1):369–71.CrossRefPubMedGoogle Scholar
  105. 105.
    Kutlubay Z, Bairamov O, Sevim A, Demirkesen C, Mat MC. Rosai-Dorfman disease: a case report with nodal and cutaneous involvement and review of the literature. Am J Dermatopathol. 2014;36(4):353–7. Scholar
  106. 106.
    Pitamber HV, Grayson W. Five cases of cutaneous Rosai-Dorfman disease. Clin Exp Dermatol. 2003;28(1):17–21.CrossRefPubMedGoogle Scholar
  107. 107.
    Al Robaee A, Banka N, Alfadley A. Phakomatosis pigmentovascularis type IIb associated with Sturge-Weber syndrome. Pediatr Dermatol. 2004;21(6):642–5. Scholar
  108. 108.
    Namiki T, Takahashi M, Nojima K, Ueno M, Hanafusa T, Tokoro S, Yokozeki H. Phakomatosis pigmentovascularis type IIb: a case with Klippel-Trenaunay syndrome and extensive dermal melanocytosis as nevus of Ota, nevus of Ito and ectopic Mongolian spots. J Dermatol. 2017;44(3):e32–3. Scholar
  109. 109.
    Fimiani M, Mazzatenta C, Rubegni P, Andreassi L. Idiopathic angiokeratoma corporis diffusum. Clin Exp Dermatol. 1997;22(4):205–6.CrossRefPubMedGoogle Scholar
  110. 110.
    Molho-Pessach V, Bargal R, Abramowitz Y, Doviner V, Ingber A, Raas-Rothschild A, Ne’eman Z, Zeigler M, Zlotogorski A. Angiokeratoma corporis diffusum in human beta-mannosidosis: report of a new case and a novel mutation. J Am Acad Dermatol. 2007;57(3):407–12. Scholar
  111. 111.
    Ghosh SK, Ghosh S, Agarwal M. Multiple giant angiokeratoma of Fordyce on the shaft of the penis masquerading as keratoacanthoma. An Bras Dermatol. 2015;90(3 Suppl 1):150–2. Scholar
  112. 112.
    Gioglio L, Porta C, Moroni M, Nastasi G, Gangarossa I. Scrotal angiokeratoma (Fordyce): histopathological and ultrastructural findings. Histol Histopathol. 1992;7(1):47–55.PubMedGoogle Scholar
  113. 113.
    Duman N, Ersoy-Evans S. Angioma serpiginosum: report of two cases suggesting type 1 mosaicism and proposal of adding it to the list of mosaic skin conditions. Int J Dermatol. 2015;54(3):e88–9. Scholar
  114. 114.
    Kalisiak MS, Haber RM. Angioma serpiginosum with linear distribution: case report and review of the literature. J Cutan Med Surg. 2008;12(4):180–3. Scholar
  115. 115.
    Kirke S, Angus B, Kesteven PJ, Calonje E, Simpson N. Localized reactive angioendotheliomatosis. Clin Exp Dermatol. 2007;32(1):45–7. Scholar
  116. 116.
    Mayor-Ibarguren A, Gomez-Fernandez C, Beato-Merino MJ, Gonzalez-Ramos J, Rodriguez-Bandera AI, Herranz-Pinto P. Diffuse reactive angioendotheliomatosis secondary to the administration of trabectedin and pegfilgrastim. Am J Dermatopathol. 2015;37(7):581–4. Scholar
  117. 117.
    Cham E, Smoller BR, Lorber DA, Victor TA, Cibull TL. Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) arising on the extremities. J Cutan Pathol. 2010;37(10):1045–52. Scholar
  118. 118.
    Kanik AB, Oh CH, Bhawan J. Disseminated cutaneous epithelioid hemangioma. J Am Acad Dermatol. 1996;35(5 Pt 2):851–3.CrossRefPubMedGoogle Scholar
  119. 119.
    Ma HJ, Zhao G, Li Y, Li DG. Tufted angioma presented with segmental hyperpigmented plaque in a young Chinese woman. J Dermatol. 2010;37(2):190–2. Scholar
  120. 120.
    Tasani M, Ancliff P, Glover M. Sirolimus therapy for children with problematic Kaposiform haemangioendothelioma and tufted angioma. Br J Dermatol. 2017.
  121. 121.
    Wang L, Liu L, Wang G, Gao T. Congenital disseminated tufted angioma. J Cutan Pathol. 2013;40(4):405–8. Scholar
  122. 122.
    Tennant LB, Mulliken JB, Perez-Atayde AR, Kozakewich HP. Verrucous hemangioma revisited. Pediatr Dermatol. 2006;23(3):208–15. Scholar
  123. 123.
    Wang L, Gao T, Wang G. Verrucous hemangioma: a clinicopathological and immunohistochemical analysis of 74 cases. J Cutan Pathol. 2014;41(11):823–30. Scholar
  124. 124.
    Kakizaki P, Valente NY, Paiva DL, Dantas FL, Goncalves SV. Targetoid hemosiderotic hemangioma—case report. An Bras Dermatol. 2014;89(6):956–9.CrossRefPubMedPubMedCentralGoogle Scholar
  125. 125.
    Mentzel T, Partanen TA, Kutzner H. Hobnail hemangioma (“targetoid hemosiderotic hemangioma”): clinicopathologic and immunohistochemical analysis of 62 cases. J Cutan Pathol. 1999;26(6):279–86.CrossRefPubMedGoogle Scholar
  126. 126.
    Kim YC, Park HJ, Cinn YW. Microvenular hemangioma. Dermatology. 2003;206(2):161–4. Scholar
  127. 127.
    Napekoski KM, Fernandez AP, Billings SD. Microvenular hemangioma: a clinicopathologic review of 13 cases. J Cutan Pathol. 2014;41(11):816–22. Scholar
  128. 128.
    Gencoglan G, Dereli T, Kazandi AC. Subungual glomus tumor: surgical and histopathologic evaluation. Cutan Ocul Toxicol. 2011;30(1):72–4. Scholar
  129. 129.
    Sandoval M, Carrasco-Zuber J, Gonzalez S. Extradigital symplastic glomus tumor of the hand: report of 2 cases and literature review. Am J Dermatopathol. 2015;37(7):560–2. Scholar
  130. 130.
    Coras B, Hohenleutner U, Landthaler M, Hohenleutner S. Spindle cell hemangioma. Dermatol Surg. 2003;29(8):875–8.PubMedGoogle Scholar
  131. 131.
    Wang L, Gao T, Wang G. Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. J Cutan Pathol. 2014;41(5):447–50. Scholar
  132. 132.
    Cyrulnik AA, Dawkins MC, Smalberger GJ, Young S, Mann RE, Jacobson MI, Friedman AJ. Kaposiform hemangioendothelioma with Kasabach-Merritt syndrome mistaken for child abuse in a newborn. Cutis. 2014;93(3):E17–20.PubMedGoogle Scholar
  133. 133.
    Reichel A, Hamm H, Wiegering V, Wiewrodt B, Neubauer H, Ernestus K, Winkler B. Kaposiform hemangioendothelioma with Kasabach-Merritt syndrome: successful treatment with sirolimus. J Dtsch Dermatol Ges. 2017;15(3):329–31. Scholar
  134. 134.
    Almohideb M, Watters AK, Gerstein W. Familial classic Kaposi sarcoma in two siblings: case report and literature review. J Cutan Med Surg. 2013;17(5):356–61. Scholar
  135. 135.
    Scott B, Griffin JR. Lymphangioma-like classic Kaposi sarcoma. Int J Dermatol. 2017;56(6):e141–2. Scholar
  136. 136.
    Dhanasekar P, Karthikeyan VS, Rajkumar N, Chandra Sistla S, Manwar Ali S, Basu D, Malathi M. Cutaneous angiosarcoma of the scalp masquerading as a squamous cell carcinoma: case report and literature review. J Cutan Med Surg. 2012;16(3):187–90. Scholar
  137. 137.
    Lu Y, Zhang M. Pemphigus herpetiformis in a patient with well‐differentiated cutaneous angiosarcoma: Case report and review of the published work. The Journal of Dermatology. 2012;39(1):89–91. Scholar
  138. 138.
    Kim HS, Kim JW, Yu DS. Acquired progressive lymphangioma. J Eur Acad Dermatol Venereol. 2007;21(3):416–7. Scholar
  139. 139.
    Zhu JW, Lu ZF, Zheng M. Acquired progressive lymphangioma in the inguinal area mimicking giant condyloma acuminatum. Cutis. 2014;93(6):316–9.PubMedGoogle Scholar
  140. 140.
    Zhu WY, Penneys NS, Reyes B, Khatib Z, Schachner L. Acquired progressive lymphangioma. J Am Acad Dermatol. 1991;24(5 Pt 2):813–5.CrossRefPubMedGoogle Scholar
  141. 141.
    Chang MB, Newman CC, Davis MD, Lehman JS. Acquired lymphangiectasia (lymphangioma circumscriptum) of the vulva: clinicopathologic study of 11 patients from a single institution and 67 from the literature. Int J Dermatol. 2016;55(9):e482–7. Scholar
  142. 142.
    Goyal M, Wankhade VH, Mukhi JI, Singh RP. Nevus lipomatosus cutaneous superficialis—a rare hamartoma: report of two cases. J Clin Diagn Res. 2016;10(10):WD01–2. Scholar
  143. 143.
    Mansur AT, Yasar S, Aydingoz IE, Goktay F, Ozdemir N, Sungurlu F. Colocalization of lipedematous scalp and nevus lipomatosus superficialis: a case report. J Cutan Pathol. 2007;34(4):342–5. Scholar
  144. 144.
    Kim DH, Park SB, Lee Y, Im M, Seo YJ, Choi SH, Lee JH. Encephalocraniocutaneous lipomatosis without neurologic anomalies. Ann Dermatol. 2012;24(4):476–8. Scholar
  145. 145.
    Gawel J, Schwartz RA, Jozwiak S. Encephalocraniocutaneous lipomatosis. J Cutan Med Surg. 2003;7(1):61–5. Scholar
  146. 146.
    Chen HW, Chen HW, Chen HL, Lai CC. Madelung disease. Am J Med Sci. 2016;352(6):654. Scholar
  147. 147.
    Tan O, Ergen D. Madelung syndrome with pubic involvement. Dermatol Surg. 2008;34(6):811–4. Scholar
  148. 148.
    Gokdemir G, Sakiz D, Koslu A. Multiple cutaneous leiomyomas of the nipple. J Eur Acad Dermatol Venereol. 2006;20(4):468–9. Scholar
  149. 149.
    Gravvanis A, Kakagia D, Papadopoulos S, Tsoutsos D. Dermal skin template for the management of multiple cutaneous leiomyomas. J Cutan Med Surg. 2009;13(2):102–5. Scholar
  150. 150.
    Berzal-Cantalejo F, Sabater-Marco V, Perez-Valles A, Martorell-Cebollada M. Desmoplastic cutaneous leiomyosarcoma: case report and review of the literature. J Cutan Pathol. 2006;33(Suppl 2):29–31. Scholar
  151. 151.
    De Giorgi V, Sestini S, Massi D, Papi F, Alfaioli B, Lotti T. Superficial cutaneous leiomyosarcoma: a rare, misleading tumor. Am J Clin Dermatol. 2008;9(3):185–7.CrossRefPubMedGoogle Scholar
  152. 152.
    Weiler L, Poulalhon N, Slama A, Guillaud-Bataille M, Thomas L. Isolated cutaneous leiomyosarcoma revealing a novel germline mutation of the fumarate hydratase gene. Br J Dermatol. 2016;175(5):1104–6. Scholar
  153. 153.
    Ilyas W, Geskin L, Joseph AK, Seraly MP. Subungual exostosis of the third toe. J Am Acad Dermatol. 2001;45(6 Suppl):S200–1.CrossRefPubMedGoogle Scholar
  154. 154.
    Russell JD, Nance K, Nunley JR, Maher IA. Subungual exostosis. Cutis. 2016;98(2):128–9.PubMedGoogle Scholar
  155. 155.
    Farooq U, Laureano AC, Miteva M, Elgart GW. Cutaneous endometriosis: diagnostic immunohistochemistry and clinicopathologic correlation. J Cutan Pathol. 2011;38(6):525–8. Scholar
  156. 156.
    Fernandez Vozmediano JM, Armario Hita JC, Cuevas Santos J. Cutaneous endometriosis. Int J Dermatol. 2010;49(12):1410–2. Scholar
  157. 157.
    Lee MS, Lee JD, Cho SH, Kim HS. Palisaded encapsulated neuroma in a zosteriform distribution. Indian J Dermatol. 2016;61(1):126. Scholar
  158. 158.
    Megahed M. Palisaded encapsulated neuroma (solitary circumscribed neuroma). A clinicopathologic and immunohistochemical study. Am J Dermatopathol. 1994;16(2):120–5.CrossRefPubMedGoogle Scholar
  159. 159.
    Kneitz H, Weyandt G, Meissner C, Gebhart E, Brocker EB. Dermal schwannoma (neurilemmoma): a peculiar foreign body reaction? Am J Dermatopathol. 2010;32(4):367–9. Scholar
  160. 160.
    Moon SE, Cho YJ, Kwon OS. Subungual schwannoma: a rare location. Dermatol Surg. 2005;31(5):592–4.CrossRefPubMedGoogle Scholar
  161. 161.
    Mendenhall WM, Kirwan JM, Morris CG, Amdur RJ, Werning JW, Mendenhall NP. Cutaneous Merkel cell carcinoma. Am J Otolaryngol. 2012;33(1):88–92. Scholar
  162. 162.
    Sparks J, Sparks M, Malone JC. Cutaneous Merkel cell carcinoma: multiple asynchronous primary lesions in a patient on immunosuppressive therapy. J Cutan Pathol. 2017;44(3):309–12. Scholar
  163. 163.
    Aloi F, Tomasini C, Pippione M. Agminated Spitz nevi occurring within a congenital speckled lentiginous nevus. Am J Dermatopathol. 1995;17(6):594–8.CrossRefPubMedGoogle Scholar
  164. 164.
    Pontoizeau J, Stefan A, Comoz F, Houlier A, Haddad V, Pissaloux D, de la Fouchardiere A. Agminated Spitz nevus arising in normal skin with redundant HRAS mutation. Eur J Dermatol. 2017;27(1):73–4. Scholar
  165. 165.
    Kato T, Suetake T, Sugiyama Y, Tabata N, Tagami H. Epidemiology and prognosis of subungual melanoma in 34 Japanese patients. Br J Dermatol. 1996;134(3):383–7.CrossRefPubMedGoogle Scholar
  166. 166.
    Sone Y, Namiki T, Munetsugu T, Ueno M, Tokoro S, Nishizawa A, Takayama K, Yokozeki H. A case of subungual melanoma with bone invasion: destructive local invasion and multiple skin metastases. J Eur Acad Dermatol Venereol. 2016;30(6):1049–50. Scholar
  167. 167.
    Alikhan A, Ibrahimi OA, Eisen DB. Congenital melanocytic nevi: where are we now? Part I. Clinical presentation, epidemiology, pathogenesis, histology, malignant transformation, and neurocutaneous melanosis. J Am Acad Dermatol. 2012;67(4):495.e1–17quiz 512–494. Scholar
  168. 168.
    Furtado S, Furtado SV, Ghosal N, Hegde AS. Fatal leptomeningeal melanoma in neurocutaneous melanosis. Pediatr Dermatol. 2012;29(3):358–61. Scholar
  169. 169.
    Matsumura M, Okudela K, Tateishi Y, Umeda S, Mitsui H, Suzuki T, Nakayama T, Inayama Y, Ohashi K. Leptomeningeal melanomatosis associated with neurocutaneous melanosis: an autopsy case report. Pathol Int. 2015;65(2):100–5. Scholar
  170. 170.
    Asgari MM, Shen L, Sokil MM, Yeh I, Jorgenson E. Prognostics factors and survival in acral lentiginous melanoma. Br J Dermatol. 2017;177:428–35. Scholar
  171. 171.
    Han JS, Won CH, Chang SE, Lee MW, Choi JH, Moon KC. Primary cutaneous balloon cell melanoma: a very rare variant. Int J Dermatol. 2014;53(11):e535–6. Scholar
  172. 172.
    Lawaetz M, Birch-Johansen F, Friis S, Eriksen JG, Kiss K, Gade S, Moller-Madsen M, Pourbordbari N, von Buchwald C. Primary mucosal melanoma of the head and neck in Denmark, 1982–2012: demographic and clinical aspects. A retrospective DAHANCA study. Acta Oncol. 2016;55(8):1001–8. Scholar
  173. 173.
    Mitteldorf C, Kempf W. Cutaneous pseudolymphoma. Surg Pathol Clin. 2017;10(2):455–76. Scholar
  174. 174.
    Moreno-Ramirez D, Garcia-Escudero A, Rios-Martin JJ, Herrera-Saval A, Camacho F. Cutaneous pseudolymphoma in association with molluscum contagiosum in an elderly patient. J Cutan Pathol. 2003;30(7):473–5.CrossRefPubMedGoogle Scholar
  175. 175.
    Terada T. Cutaneous pseudolymphoma: a case report with an immunohistochemical study. Int J Clin Exp Pathol. 2013;6(5):966–72.PubMedPubMedCentralGoogle Scholar
  176. 176.
    Kim IS, Kim BR, Youn SW. Differentiation of Jessner’s lymphocytic infiltration of the skin from various chronic cutaneous lupus erythematosus subtypes by quantitative computer-aided image analysis. Dermatology. 2016;232(1):57–63. Scholar
  177. 177.
    Krieger BL. Lymphocytic infiltration of the skin (Jessner). Arch Dermatol. 1969;100(2):247–8.CrossRefPubMedGoogle Scholar
  178. 178.
    Ziemer M, Eisendle K, Muller H, Zelger B. Lymphocytic infiltration of the skin (Jessner-Kanof) but not reticular erythematous mucinosis occasionally represents clinical manifestations of Borrelia-associated pseudolymphoma. Br J Dermatol. 2009;161(3):583–90. Scholar
  179. 179.
    Nakada T, Sueki H, Iijima M. Disseminated pagetoid reticulosis (Ketron-Goodman disease): six-year follow-up. J Am Acad Dermatol. 2002;47(2 Suppl):S183–6.CrossRefPubMedGoogle Scholar
  180. 180.
    Steffen C. Ketron-Goodman disease, Woringer-Kolopp disease, and pagetoid reticulosis. Am J Dermatopathol. 2005;27(1):68–85.CrossRefPubMedGoogle Scholar
  181. 181.
    Ahn CS, AL A, Sangueza OP. Mycosis fungoides: an updated review of clinicopathologic variants. Am J Dermatopathol. 2014;36(12):933–948; quiz 949–51. Scholar
  182. 182.
    Hwang ST, Janik JE, Jaffe ES, Wilson WH. Mycosis fungoides and Sezary syndrome. Lancet. 2008;371(9616):945–57. Scholar
  183. 183.
    Lehman JS, Cook-Norris RH, Weed BR, Weenig RH, Gibson LE, Weaver AL, Pittelkow MR. Folliculotropic mycosis fungoides: single-center study and systematic review. Arch Dermatol. 2010;146(6):607–13. Scholar
  184. 184.
    Martinez-Escala ME, Gonzalez BR, Guitart J. Mycosis fungoides variants. Surg Pathol Clin. 2014;7(2):169–89. Scholar
  185. 185.
    Munoz-Gonzalez H, Molina-Ruiz AM, Requena L. Clinicopathologic variants of mycosis fungoides. Actas Dermosifiliogr. 2017;108(3):192–208. Scholar
  186. 186.
    Reddy K, Bhawan J. Histologic mimickers of mycosis fungoides: a review. J Cutan Pathol. 2007;34(7):519–25. Scholar
  187. 187.
    Chan BC, Stefanato CM, Moonim MT, Morris SL, Fields P, Dasgupta D, Therianou A, Whittaker SJ. Diffuse large B-cell lymphoma developing in erythrodermic cutaneous T-cell lymphoma: a case series. Br J Dermatol. 2017.
  188. 188.
    Russell-Jones R. Diagnosing erythrodermic cutaneous T-cell lymphoma. Br J Dermatol. 2005;153(1):1–5. Scholar
  189. 189.
    Vandersee S, Humme D, Terhorst D, Almohamad A, Mobs M, Beyer M. Evaluation of blood parameters for the monitoring of erythrodermic cutaneous T-cell lymphoma. J Dtsch Dermatol Ges. 2015;13(1):30–6. Scholar
  190. 190.
    Ohtsuka M, Miura T, Yamamoto T. Clinical characteristics, differential diagnosis, and treatment outcome of subcutaneous panniculitis-like T-cell lymphoma: a literature review of published Japanese cases. Eur J Dermatol. 2017;27(1):34–41. Scholar
  191. 191.
    Yim JH, Kim MY, Kim HO, Cho B, Chung NG, Park YM. Subcutaneous panniculitis-like T-cell lymphoma in a 26-month-old child with a review of the literature. Pediatr Dermatol. 2006;23(6):537–40. Scholar
  192. 192.
    Quintanilla-Martinez L, Ridaura C, Nagl F, Saez-de-Ocariz M, Duran-McKinster C, Ruiz-Maldonado R, Alderete G, Grube P, Lome-Maldonado C, Bonzheim I, Fend F. Hydroa vacciniforme-like lymphoma: a chronic EBV+ lymphoproliferative disorder with risk to develop a systemic lymphoma. Blood. 2013;122(18):3101–10. Scholar
  193. 193.
    Zhang X, Wang T, Wang L. Hydroa vacciniforme-like lymphoma in tibetan children: 2 cases and a literature review. Am J Dermatopathol. 2017.
  194. 194.
    Choi YL, Park JH, Namkung JH, Lee JH, Yang JM, Lee ES, Lee DY, Jang KT, Ko YH. Extranodal NK/T-cell lymphoma with cutaneous involvement: ‘nasal’ vs. ‘nasal-type’ subgroups--a retrospective study of 18 patients. Br J Dermatol. 2009;160(2):333–7. Scholar
  195. 195.
    Kim HJ, Kim SH, Oh SH. CD56-negative extranodal NK/T-cell lymphoma, nasal type, with extranasal cutaneous involvement. Ann Dermatol. 2015;27(5):618–20. Scholar
  196. 196.
    Yu WW, Hsieh PP, Chuang SS. Cutaneous EBV-positive gammadelta T-cell lymphoma vs. extranodal NK/T-cell lymphoma: a case report and literature review. J Cutan Pathol. 2013;40(3):310–6. Scholar
  197. 197.
    Bogle MA, Riddle CC, Triana EM, Jones D, Duvic M. Primary cutaneous B-cell lymphoma. J Am Acad Dermatol. 2005;53(3):479–84. Scholar
  198. 198.
    Sanusi T, Sun L, Wang C, Zhao Y, Huang C. Primary cutaneous diffuse large B-cell lymphoma of the face. J Dtsch Dermatol Ges. 2016;14(4):423–6. Scholar
  199. 199.
    Barnes M, Van L, DeLong L, Lawley LP. Severity of cutaneous findings predict the presence of systemic symptoms in pediatric maculopapular cutaneous mastocytosis. Pediatr Dermatol. 2014;31(3):271–5. Scholar
  200. 200.
    Lange M, Niedoszytko M, Nedoszytko B, Lata J, Trzeciak M, Biernat W. Diffuse cutaneous mastocytosis: analysis of 10 cases and a brief review of the literature. J Eur Acad Dermatol Venereol. 2012;26(12):1565–71. Scholar
  201. 201.
    Neri I, Virdi A, Balestri R, Patrizi A. Diffuse cutaneous mastocytosis: a heterogeneous disease. Arch Dis Child. 2013;98(8):607. Scholar
  202. 202.
    Bourji L, Kurban M, Abbas O. Solitary mastocytoma mimicking granuloma faciale. Int J Dermatol. 2014;53(12):e587–8. Scholar
  203. 203.
    Hannaford R, Rogers M. Presentation of cutaneous mastocytosis in 173 children. Australas J Dermatol. 2001;42(1):15–21.CrossRefPubMedGoogle Scholar
  204. 204.
    Lee HP, Yoon DH, Kim CW, Kim TY. Solitary mastocytoma on the palm. Pediatr Dermatol. 1998;15(5):386–7.CrossRefPubMedGoogle Scholar
  205. 205.
    Comfere NI, Gonzalez Santiago TM, Peters MS, Knudson RA, Ketterling RP, Gibson LE. Cutaneous extramedullary plasmacytoma: clinical, prognostic, and interphase cytogenetic analysis. Am J Dermatopathol. 2013;35(3):357–63. Scholar
  206. 206.
    Tsang DS, Le LW, Kukreti V, Sun A. Treatment and outcomes for primary cutaneous extramedullary plasmacytoma: a case series. Curr Oncol. 2016;23(6):e630–46. Scholar
  207. 207.
    Wuu A, Bangert SD, Weber DM, Hymes SR. Primary cutaneous plasmacytoma. Cutis. 2014;93(6):E19–21.PubMedGoogle Scholar
  208. 208.
    Gerds AT, Dao KH. Polycythemia vera management and challenges in the community health setting. Oncology. 2017;92(4):179–89. Scholar
  209. 209.
    Ongenae K, Janssens A, Noens L, Wieme N, Geerts ML, Beele H, Naeyaert JM. Erythromelalgia: a clue to the diagnosis of polycythemia vera. Dermatology. 1996;192(4):408–10.CrossRefPubMedGoogle Scholar
  210. 210.
    Babina T, Miller L, Thomas B. Leukemia cutis. J Drugs Dermatol. 2012;11(3):416–7.PubMedGoogle Scholar
  211. 211.
    Cruz Manzano M, Ramirez Garcia L, Sanchez Pont JE, Velazquez Manana AI, Sanchez JL. Rosacea-like leukemia cutis: a case report. Am J Dermatopathol. 2016;38(8):e119–21. Scholar
  212. 212.
    Ratnam KV, Khor CJ, Su WP. Leukemia cutis. Dermatol Clin. 1994;12(2):419–31.CrossRefPubMedGoogle Scholar
  213. 213.
    Marcoval J, Penin RM, Llatjos R, Martinez-Ballarin I. Cutaneous metastasis from lung cancer: retrospective analysis of 30 patients. Australas J Dermatol. 2012;53(4):288–90. Scholar
  214. 214.
    Junqueira AL, Corbett AM, Oliveira Filho J, Nasser Kda R, Haddad NN, Tebet AC. Cutaneous metastasis from gastrointestinal adenocarcinoma of unknown primary origin. An Bras Dermatol. 2015;90(4):564–6. Scholar
  215. 215.
    Triantafyllou S, Georgia D, Gavriella-Zoi V, Dimitrios M, Stulianos K, Theodoros L, Georgios Z, Dimitrios T. Cutaneous metastases from esophageal adenocarcinoma. Int Surg. 2015;100(3):558–61. Scholar
  216. 216.
    Inadomi T. Sister Mary Joseph’s nodule: a clue to finding pancreatic cancer in a patient previously affected by gastric cancer. Eur J Dermatol. 2005;15(6):492–4.PubMedGoogle Scholar
  217. 217.
    Pereira WA, Humaire CR, Silva CS, Fernandes LH. Sister Mary Joseph’s nodule: a sign of internal malignancy. An Bras Dermatol. 2011;86(4 Suppl 1):S118–20.CrossRefPubMedGoogle Scholar
  218. 218.
    Renner R, Sticherling M. Sister Mary Joseph’s nodule as a metastasis of gallbladder carcinoma. Int J Dermatol. 2007;46(5):505–7. Scholar
  219. 219.
    Harvey G, Cochrane T. Carcinoma en cuirasse; primary lesion in stomach. AMA Arch Derm Syphilol. 1950;62(5):651–4.CrossRefPubMedGoogle Scholar
  220. 220.
    Mullinax K, Cohen JB. Carcinoma en cuirasse presenting as keloids of the chest. Dermatol Surg. 2004;30(2 Pt 1):226–8.PubMedGoogle Scholar
  221. 221.
    Xu P, Tan C. Primary breast carcinoma en cuirasse. J Dtsch Dermatol Ges. 2016;14(6):614–6. Scholar

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© Springer Nature Singapore Pte Ltd. and People's Military Medical Press 2018

Authors and Affiliations

  • Yong-Hang Zhu
    • 1
  • Gui-Xiu Zhang
    • 2
  • Li Tang
    • 3
  • Xiao-Jie Li
    • 4
  • Wen-Yuan Zhu
    • 4
  • Ru-Zhi Zhang
    • 5
  • Ming-Yu Xia
    • 6
  • Lei Wang
    • 7
  • Ying Ren
    • 8
  • Hui-Pu Zhou
    • 9
  • De-Hai Pan
    • 10
  • Li-Jian Xiang
    • 11
  • Jin-Fa Su
    • 12
  • Hui Zhang
    • 13
  • Juan Du
    • 14
  • Mai-Hua Hou
    • 4
  • Dong-Lai Ma
    • 15
  • Shu-Qin Lv
    • 16
  • Xi-Chuan Yang
    • 17
  • Jie Gao
    • 18
  • Ting Lin
    • 19
  • Shao-Wen Peng
    • 17
  • Zhi-Ping Sun
    • 20
  • Li Yang
    • 21
  • Cheng Tan
    • 22
    Email author
  • Ji-Ling Zhang
    • 23
  • Yan Wu
    • 24
  • Hong Zhang
    • 25
  • Gang Liu
    • 26
  • Bao-Chun Li
    • 27
  • Shun-Fan Li
    • 28
  • Lan Yang
    • 15
  • Jie Yan
    • 15
  • Yang Guan
    • 29
  • Yin Xiao
    • 30
  • Yan Yan
    • 15
  • Zhi-Fang Zhai
    • 17
  • Shan Tang
    • 31
  • Zhong Xie
    • 32
  • Feng Wu
    • 33
  • Xiao-Mei Zhang
    • 34
  • Jian-Fang Sun
    • 35
  • Wen-Hai Li
    • 36
  • Mei Cai
    • 37
  • Chun-Mei Zhang
    • 38
  • Xian Zhang
    • 39
  • Gang Wang
    • 7
  • Hong-Hao Jiang
    • 33
  • Jiang Jin
    • 14
  • Xiong-Ming Pu
    • 40
  • Jian-Min Chang
    • 36
  • Yan Lu
    • 4
  • Xiao-Jun Zhu
    • 41
  • Cun-Cai Zhou
    • 42
  • Shu-Fang Qiao
    • 29
  • Jian-Ping Liang
    • 43
  • Zhi-Xin Song
    • 44
  • Yi-Ming Xu
    • 40
  • Jun Peng
    • 45
  • Hong-Zhong Jin
    • 15
  • Chun-Xing Xu
    • 46
  • Jing Fang
    • 4
  • Chuan-Ping Xing
    • 47
  • Xiao-Bing Pi
    • 14
  • Dian-Ying Zhuang
    • 48
  • Jia-Bi Wang
    • 15
  • Jian-Ying Zeng
    • 15
  • Min Huang
    • 49
  • Chun-Yang Li
    • 50
  • Bing-Nan Cui
    • 51
  • Xiao-Yan Guo
    • 52
  • Tong Lin
    • 53
  • Bing-Sen Qiu
    • 54
  • Bin Su
    • 15
  • Xue-Jun Zhu
    • 32
  • Pei-Hua Song
    • 10
  • Guang-Cai Xiang
    • 10
  • Guang-Ren Liu
    • 14
  • Sheng-Shun Tan
    • 55
  • Yi-Qun Jiang
    • 56
  • Min Zheng
    • 57
  • Jin Hu
    • 58
  • Guang-He Yang
    • 59
  • Zheng Ge
    • 60
  • Jing Chen
    • 61
  • Lin Cai
    • 62
  • Sheng Wang
    • 63
  • An Liu
    • 59
  • Xian Jiang
    • 64
  1. 1.Department of DermatologyLiaoning General Hospital of Nuclear IndustryXingchengChina
  2. 2.Department of DermatologyThe First People’s Hospital of YunnanKunmingChina
  3. 3.Department of DermatologyTianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjinChina
  4. 4.Department of DermatologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingChina
  5. 5.Department of DermatologyThe Third Affiliated Hospital of Suzhou UniversityChangzhouChina
  6. 6.Nanjing Medical UniversityNanjingChina
  7. 7.Institute of Dermatology of Chinese PLA, Xijing HospitalThe Fourth Military Medical UniversityXi’anChina
  8. 8.Department of DermatologyAffiliated Hospital of Chengde Medical CollegeChengdeChina
  9. 9.Department of DermatologyThe People’s Hospital of ShanweiShanweiChina
  10. 10.Department of DermatologyChina-Japan Friendship HospitalBeijingChina
  11. 11.Department of DermatologyThe First Hospital of HangzhouHangzhouChina
  12. 12.Department of DermatologySkin Disease Prevention CenterJingmenChina
  13. 13.Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina
  14. 14.Department of DermatologyPeking University People’s HospitalBeijingChina
  15. 15.Department of Dermatology, Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  16. 16.Department of DermatologyFujian Dongshan County HospitalFujianChina
  17. 17.Department of Dermatology and Venereology, Southwest HospitalThird Military Medical UniversityChongqingChina
  18. 18.Department of Dermatology and VenereologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingChina
  19. 19.Department of DermatologyGeneral Hospital of Guangzhou Military Command of PLAGuangzhouChina
  20. 20.Department of DermatologyDongguan Donghua HospitalGuangzhouChina
  21. 21.Department of Dermatology, Xijing Hospital, Institute of PLA DermatologyThe Fourth Military Medical UniversityXi’anChina
  22. 22.Department of DermatologyAffiliated Hospital of Nanjing University of Chinese MedicineNanjingChina
  23. 23.Department of DermatologyThe Affiliated Hospital of Zunyi Medical CollegeZunyiChina
  24. 24.Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  25. 25.Department of DermatologyAir Force General Hospital, PLABeijingChina
  26. 26.Department of Plastic SurgeryTianjin Changzheng HospitalTianjinChina
  27. 27.Department of DermatologyXian Yang Central HospitalXian YangChina
  28. 28.Department of DermatologyAffiliated Hospital of Guangzhou Medical UniversityGuangzhouChina
  29. 29.Department of DermatologyTianjin Changzheng HospitalTianjinChina
  30. 30.Department of PathologyTianjin Changzheng HospitalTianjinChina
  31. 31.Institute of Dermatology and STD of Fujian ProvinceFuzhouChina
  32. 32.Department of DermatologyPeking University First HospitalBeijingChina
  33. 33.Department of Dermatology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  34. 34.Panyu Chronic Disease HospitalGuangzhouChina
  35. 35.Institute of DermatologyChinese Academy of Medical SciencesNanjingChina
  36. 36.Department of DermatologyBeijing HospitalBeijingChina
  37. 37.Department of Dermatology, The Second Affiliated HospitalKunming Medical CollegeKunmingChina
  38. 38.Department of Dermatology, The Second HospitalShandong UniversityJinanChina
  39. 39.Department of Dermatology, Nantong Rich HospitalFourth Clinical College of Yangzhou UniversityNantongChina
  40. 40.Department of DermatologyThe People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiChina
  41. 41.Department of DermatologySecond Affiliated Hospital of Sun Yat-Sen UniversityGuangZhouChina
  42. 42.Department of Medical Cosmetology, Heping HospitalThe Changzhi Medical CollegeChangzhiChina
  43. 43.Department of DermatologyDatong Fifth HospitalDatongChina
  44. 44.Department of SurgeryQianan People’s HospitalQiananChina
  45. 45.Department of DermatologyCangzhou People’s HospitalCangzhouChina
  46. 46.Department of DermatologyThe Third Affiliated Hospital of Souzhou UniversityChangzhouChina
  47. 47.Department of PathologyLanzhou General Hospital of Lanzhou Military CommandLanzhouChina
  48. 48.Department of DermatologyChaoyang Dafeng Hospital of ShantouShantouChina
  49. 49.Department of DermatologyShenzhen Center for Chronic Disease ControlShenzhenChina
  50. 50.Department of Dermatology, Qilu HospitalShandong UniversityJinanChina
  51. 51.Department of Dermatology, Guang’anmen HospitalChina Academy of Traditional Chinese MedicineBeijingChina
  52. 52.Department of DermatologyTangshan Union HospitalTangshanChina
  53. 53.Department of Dermatology, Institute of Dermatology and Hospital for Skin DiseasesChinese Academy of Medical Sciences & Peking Union Medical CollageNanjingChina
  54. 54.Department of DermatologyHuashan Hospital of Fudan UniversityShanghaiChina
  55. 55.Department of DermatologySecond Hospital of Xi’an Jiaotong UniversityXi’anChina
  56. 56.Institute of Dermatology, Peking Union Medical CollegeChinese Academy of Medical ScienceNanjingChina
  57. 57.Department of DermatologyThe Second Affiliated Hospital of Zhejiang Medical UniversityHangzhouChina
  58. 58.Department of DermatologyAffiliated Hospital of Children Capital Institute of PediatricsBeijingChina
  59. 59.Department of DermatologyHubei Jianghan Oilfield Central HospitalQianjiangChina
  60. 60.Department of HematologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingChina
  61. 61.Department of DermatologyTianjin Gong’an HospitalTianjinChina
  62. 62.Department of DermatologyPeople’s Hospital of Beijing UniversityBeijingChina
  63. 63.Department of Dermatology, West China HospitalSichuan UniversityChengduChina
  64. 64.Department of Dermatology and VenereologyWest China Hospital of Sichuan UniversityChengduChina

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