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Nevadensin

  • Zhao Zhang
  • Ling-Lei Kong
  • Nai-Hong ChenEmail author
Chapter

Abstract

Stone Chlorophytum is the folk antituberculous herb. Nevadensin is extracted from Lysionotus pauciflorus Maxim, which has been used for the adjuvant therapy of cervical lymph node tuberculosis, tuberculosis, bone tuberculosis, and bronchitis treatment. Adverse reactions are mainly nausea, vomiting, diarrhea and abdominal discomfort, etc. With the improvement of the extraction technology of nevadensin, its biological activity is improved continuously, which will surely be expanding its application areas.

Keywords

Nevadensin Tuberculosis Bronchitis 

References

  1. 1.
    China Pharmacopoeia Committee, Pharmacopoeia of the People’s Republic of China. The first division of 1997 edition. Beijing: People’s Medical Publishing House Press; 1977. p. 141.Google Scholar
  2. 2.
    State Administration of Traditional Chinese Medicine, Editorial Board of the Chinese materia medica. The Chinese materia medica: the 20th volumes. Shanghai: Shanghai Science and Technology Press; 1999. p. 498–500.Google Scholar
  3. 3.
    Farkas L, Nogradi M, Sudarsanam V, et al. Constituents of Iva species V. Isolation, structure, and synthesis of nevadensin, a new flavone from Iva nevadensis M. E. Jones and Iva acerosa (Nutt.) Jackson. J Org Chem. 1966;31:3228–32.CrossRefGoogle Scholar
  4. 4.
    Mabry J. The systematic identification of flavonoids, vol. 107. New York: Springer; 1970.CrossRefGoogle Scholar
  5. 5.
    Xu Y, Hu ZB, Feng SC, et al. The research of antituberculous active ingredients of Lysionotius pauciflorus Maxim I: the separation and identification of Nevadensin. Acta Pharm Sin. 1979;14(7):447–8.Google Scholar
  6. 6.
    Tang CF, Xi GL, Gu KJ, et al. Synthesis of tuberculostatic nevadensin and its analogs K. Chin Pharm J. 1981;16(3):55–6.Google Scholar
  7. 7.
    He XZ, Luo GY, Wang ZN. The anti-inflammatory effect of Nevadensin. Tradit Chin Med J. 1985;10(11):516–8.Google Scholar
  8. 8.
    Liu H, Yan C, Li C, et al. LC-MS/MS determination of nevadensin in rat plasma and its application in pharmacokinetic studies. J Pharm Biomed Anal. 2013;74:56–61.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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