• Yue-Hua Wang
  • Wei-Han Li
  • Guan-Hua DuEmail author


Naringin, also called naringoside, hesperidin, and isohesperidin, is a kind of flavanone compound extracted from immature or nearly mature outer layer of C. paradisi Macfad which belongs to Citrus grandis (L.) Osbeck. Naringin has many biological activities and pharmacological effects including antioxidant, antiaging, anticancer, antimicrobial, hypoglycemic, lowering blood pressure, and prevention of atherosclerosis, and it has been used in fields of medicine and cosmetic. In addition, naringin can be used as natural colorants and flavor modifiers in food industry.


Naringin Naringoside Analgesic Anti-inflammation 


  1. 1.
    Li JD, Huang QR. Research progress on extraction, isolation and pharmacological effects of naringin. J N Pharm. 2014;11(7):67–9.Google Scholar
  2. 2.
    Harvey EM, Rygg GL. Colorimetric determination of naringin. Plant Physiol. 1936;11(2):463–5.CrossRefGoogle Scholar
  3. 3.
    Booth AN, Jones FT, Deeds F. Metabolic and glucosuria studies on naringin and phloridzin. J Biol Chem 1958; 233(2): 280–2.Google Scholar
  4. 4.
    Hagen RE, Dunlap WJ, Mizelle JW, et al. A chromatographic-fluorometric method for determination of naringin, naringenin rutinoside, and related flavanone blycosides in grapefruit juice and juice sacs. Anal Biochem. 1965;12(3):472–82.CrossRefGoogle Scholar
  5. 5.
    Kalman SM, Clewe ER. Respiration of ascites tumor cells: effects of quercitrin and naringin. Stanford Med Bull. 1953;11(4):216–7.PubMedGoogle Scholar
  6. 6.
    Lambev I, Krushkov I, Zheliazkov D, et al. Antiexudative effect of naringin in experimental pulmonary edema and peritonitis. Eksp Med Morfol. 1980;19(4):207–12.PubMedGoogle Scholar
  7. 7.
    Lambev I, Belcheva A, Zhelyazkov D. Flavonoids with antioxidant action (naringin and rutin) and the release of mastocytic and nonmastocytic histamine. Acta Physiol Pharmacol Bulg. 1980;6(2):70–5.PubMedGoogle Scholar
  8. 8.
    Jia DY, Yao K, Tan M, et al. Ethanol extract processing of naringin from pummelo pericarp. Chin Tradit Herb Drug. 2002;33(9):801–2.Google Scholar
  9. 9.
    Xie RF, Wen SE, Li Y, et al. Study on the antiinflammation and analgesia of naringin. J Human Normal Univ (Med Sci). 2011;8(4):5–12.Google Scholar
  10. 10.
    Kawaguchi K, Kikuchi S, Hasegawa H, et al. Suppression of lipopolysaccharide- induced tumor necrosis factor-release and liver injury in mice by naringin. Eur J Pharmacol. 1999;368(2–3):245–50.CrossRefGoogle Scholar
  11. 11.
    Wu K, Huang RN, You Q, et al. Protective effect of naringin on myocardium of diabetic rats. Int J Cardiovasc Dis. 2012;39(5):302–5.Google Scholar
  12. 12.
    Gopinath K, Sudhandiran G. Naringin modulates oxidative stress and inflammation in 3 nitropropionic acid induced neurodegeneration through the activation of nuclear factor erythroid 2 related factor 2 signalling pathway. Neuroscience. 2012;227:134–43.CrossRefGoogle Scholar

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© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical Screening, Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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