• Ling-Lei Kong
  • Guan-Hua DuEmail author


Artemisinin is an antimalarial lactone derived from qinghao. Clinically, artemisinin is mainly used to treat malaria symptoms, malignant cerebral malaria, uncomplicated malaria, and severe malaria. Combined with different antimalarial can delay and prevent resistance of malaria parasites. Artemisinin combination therapies (ACT) have been recommended by the WHO as the first-line therapy for P. falciparum malaria worldwide. The discovery of artemisinin has completely changed the treatment of malaria. With the widespread use of artemisinin and its derivatives, the resistance of Plasmodium to these drugs has emerged, which pose a new challenge to the treatment of malaria. Therefore, a new generation of artemisinin drugs should have a broader application prospects.


Artemisinin Malaria Artemisinin combination therapies (ACT) 


  1. 1.
    Wang M-y. History of artemisinins development. Chin J Nat. 2012;34:44–7.Google Scholar
  2. 2.
    Miller LH, Su X. Artemisinin: discovery from the Chinese herbal garden. Cell. 2011;146(6):855–8.CrossRefGoogle Scholar
  3. 3.
    Tu Y. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med. 2011;17(10):1217–20.CrossRefGoogle Scholar
  4. 4.
    Collaboration Research Group for Qinghaosu. A new sesquiterpene lactone—qinghaosu. KexueTongbao. 1977;22:142.Google Scholar
  5. 5.
    Collaboration Research Group for Qinghaosu. Crystal structure and absolute configuration of artemisinin. Sci China. 1979;11:78–92.Google Scholar
  6. 6.
    Tu YY. Qinghao and qinghaosu derivative drugs. Beijing: Chemical Industry Press; 2009.Google Scholar
  7. 7.
    Li Y, Wu YL. How Chinese scientists discovered qinghaosu (artemisinin) and developed its derivatives? What are the future perspectives? Med Trop (Mars). 1998;58(3 Suppl):9–12.Google Scholar
  8. 8.
    Collaboration research group for Qinghaosu. Studies on new anti-malarial drug qinghaosu. YaoxueTongbao. 1979;2:49–53.Google Scholar
  9. 9.
    Pharmacology Research Laboratory of the Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine. Pharmacologic study of Qinghao. XINYIYAOXUEZAZHI. 1979;1:25–35.Google Scholar
  10. 10.
    Bhaw-Luximon A, Jhurry D. Artemisinin and its derivatives in cancer therapy: status of progress, mechanism of action, and future perspectives. Cancer Chemother Pharmacol. 2017;79(3):451–66.CrossRefGoogle Scholar
  11. 11.
    Malaria Expert Advisory Committee of Ministry. Use of antimalarial principle and regimens in China. Chin J Parasit Dis Control. 2002;15:129–30.Google Scholar
  12. 12.
    Cui L, Su XZ. Discovery, mechanisms of action and combination therapy of artemisinin. Expert Rev Anti Infect Ther. 2009;7(8):999–1013.CrossRefGoogle Scholar
  13. 13.
    Meshnick SR. Artemisinin: mechanisms of action, resistance and toxicity. Int J Parasitol. 2002;32(13):1655–60.CrossRefGoogle Scholar

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© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical Screening, Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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