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Artemisinin

  • Ling-Lei Kong
  • Guan-Hua DuEmail author
Chapter

Abstract

Artemisinin is an antimalarial lactone derived from qinghao. Clinically, artemisinin is mainly used to treat malaria symptoms, malignant cerebral malaria, uncomplicated malaria, and severe malaria. Combined with different antimalarial can delay and prevent resistance of malaria parasites. Artemisinin combination therapies (ACT) have been recommended by the WHO as the first-line therapy for P. falciparum malaria worldwide. The discovery of artemisinin has completely changed the treatment of malaria. With the widespread use of artemisinin and its derivatives, the resistance of Plasmodium to these drugs has emerged, which pose a new challenge to the treatment of malaria. Therefore, a new generation of artemisinin drugs should have a broader application prospects.

Keywords

Artemisinin Malaria Artemisinin combination therapies (ACT) 

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Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical Screening, Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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