• Yan Zhao
  • Li-Da Du
  • Guan-Hua Du


Arecoline is extracted from Areca catechu L., and it is the most important alkaloid in it. Arecoline has the effect of antiparasite and is promoting the motility of the gastrointestinal smooth muscle. It activates the M and N cholinergic receptors, excites the nervous system, promotes the body excitability, and improves the ability of learning and memory. The application of arecoline is rare at present mainly due to its adverse effects. However, as an important traditional Chinese medicine, areca still has important value in clinical practice, especially in compatibility of herbs.


Arecoline Alkaloid Antiparasite Cholinergic drugs 


  1. 1.
    Peng W, Liu YJ, Wu N, et al. Areca catechu l. (arecaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. J Ethnopharmacol. 2015;164:340–56.CrossRefGoogle Scholar
  2. 2.
    Zheng ZH. Modern research and application of traditional Chinese medicine. Beijing: Academic; 1999.Google Scholar
  3. 3.
    Wang G, Hu B. Research progress of arecoline. Int J Pathol Clin Med. 2010;30(2):171–5.Google Scholar
  4. 4.
    Ghelardini C, Galeotti N, Lelli C, et al. M1 receptor activation is a requirement for arecoline analgesia. Farmaco. 2001;56(5–7):383–5.CrossRefGoogle Scholar
  5. 5.
    Yang YR, Chang KC, Chen CL, et al. Arecoline excites rat locus coeruleus neurons by activating the m2-muscarinic receptor. Chin J Physiol. 2000;43(1):23–8.PubMedGoogle Scholar
  6. 6.
    Xie DP, Chen LB, Liu CY, et al. Arecoline excites the colonic smooth muscle motility via m3 receptor in rabbits. Chin J Physiol. 2004;47(2):89–94.PubMedGoogle Scholar
  7. 7.
    Li B, Zhou XZ, Li JY, Yang YJ, Niu JR, Wei XJ, Liu XW, Li JS, Zhang JY. Determination and pharmacokinetic studies of arecoline in dog plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;969:12–8.CrossRefGoogle Scholar
  8. 8.
    Saikia JR, Schneeweiss FH, Sharan RN. Arecoline-induced changes of poly-adp-ribosylation of cellular proteins and its influence on chromatin organization. Cancer Lett. 1999;139(1):59–65.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Pharmacy DepartmentQingdao Municipal HospitalQingdaoChina
  2. 2.School of Biomedical SciencesChinese University of Hong KongHong KongChina
  3. 3.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical Screening, Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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