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Vinblastine and Vincristine

  • You-Wen Zhang
  • Xiang-Ying Kong
  • Jin-Hua Wang
  • Guan-Hua DuEmail author
Chapter

Abstract

Vinblastine and vincristine are all extracted from Catharanthus roseus, which is a common Apocynaceae ornamental plant. Vinblastine and vincristine drugs have a strong inhibitory effect on monozygotic leukemia, breast cancer, liver cancer, ovarian cancer, head and neck cancer, testicular cancer, solid sarcoma, and malignant melanin in a variety of spontaneous or transplanted lymphocytic leukemia. Although the structure of vinblastine and vincristine is very similar, there are some differences in pharmacological effects, and there is no cross-resistance. The mechanism of vinblastine and vincristine is similar as the cell cycle-specific antineoplastic agents. Clinical applications of vinblastine and vincristine are very broad, especially in China. Vinblastine sulfate injection as the main application form is used intravenously to treat Hodgkin lymphoma, lymphocytic leukemia, testis tumor, and choriocarcinoma as first-line therapy in clinical practice according to ABVD method. However, antitumor effects still face challenges, and have a long way to go. The process of research and development of vinblastine drugs will provide us more meaningful revelations.

Keywords

Vinblastine and vincristine Alkaloid Antitumor 

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Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  • You-Wen Zhang
    • 1
  • Xiang-Ying Kong
    • 2
  • Jin-Hua Wang
    • 3
  • Guan-Hua Du
    • 3
    Email author
  1. 1.Beijing Key Laboratory of Anti-infective Agents, Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijingChina
  3. 3.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical Screening, Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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