• Shi-Feng Chu
  • Ling-Lei Kong
  • Nai-Hong ChenEmail author


Gossypol is extracted from the roots, stems, leaves, and seeds of the plant cotton. Amounting evidences showed that gossypol impaired the sperm quality significantly, and it was the world’s first male contraceptive. However, due to the presence of hypokalemia and irreversible antifertility risk of gossypol, the clinical indications of male contraceptives are not approved by the Chinese Food and Drug Administration. At present, gossypol and its derivatives are mainly used for female uterine fibroids, functional uterine bleeding, and endometriosis treatment. In addition, the treatment of gossypol and its derivatives in the tumor is gradually confirmed clinically.


Gossypol Contraceptive Tumor 


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© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Bioactive Substances and Functions of Natural MedicinesInstitute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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