Ginsenoside Rg3

  • Zhen-Zhen Wang
  • Ling-Lei Kong
  • Nai-Hong ChenEmail author


Ginsenoside Rg3 is a dammarane tetracyclic triterpenoid saponin found in natural ginseng, which belongs to the protopanaxadiol. It is also the natural ingredient with prominent activity extracted from red ginseng (processed ginseng). Ginsenoside Rg3 is mainly used in the clinical treatment or adjuvant therapy of cancer. In addition, it improves and prevents the common diseases in the elderly such as cardiovascular disease, coronary heart disease, limb weakness, difficulty walking, and loss of memory. It also has a certain biological activity in antiviral, radiosensitization, and treatments of chronic obstructive pulmonary disease. Ginsenoside Rg3 has a wide safety range, good oral absorption, and the characteristics of multi-target, multi-link, and multi-effect on the antitumor effect. Ginsenoside Rg3 is the active ingredient of Shenyi (参一) capsule which is a kind of traditional Chinese anticancer medicine developed in China. Further study on the antitumor mechanism of ginsenoside Rg3 will be helpful to the clinical application of this drug. Extraction of more compounds from the ginseng and red ginseng will be benefit for the findings of new important drugs to contribute to human health.


Ginsenoside Rg3 Antitumor Shenyi capsule 


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Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Bioactive Substances and Functions of Natural MedicinesInstitute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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