• Shi-Feng Chu
  • Ling-Lei Kong
  • Nai-Hong ChenEmail author


Cepharanthine is diclofenac quinoline alkaloid isolated from rhizome of Stephania japonica. It could stimulate the reticuloendothelial system, then activate hematopoietic tissue, and promote myeloproliferation. The major clinical application of cepharanthine is to improve their immunity impaired by chemotherapy or radiotherapy in tumor patients. In addition, cepharanthine can increase the sensitivity of antitumor drugs. Now, it is commonly used as an adjuvant drug for anticancer treatment. In addition, it is also used as anti-pneumoconiosis drugs in China.


Cepharanthine Myeloproliferation Tumor Pneumoconiosis 


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© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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