• Zhao Zhang
  • Ling-Lei Kong
  • Nai-Hong ChenEmail author


Sinomenine is derived from Caulis Sinomenii, which is mainly used for the treatment of rheumatoid arthritis and other types of rheumatism and arrhythmia in clinical practice. Sinomenine has anti-inflammatory, immunosuppressive, analgesic sedation, antiarrhythmic, detoxification, and other pharmacological effects, while the half-life of sinomenine is short. In addition, sinomenine also causes a strong histamine release, which leads to rash, gastrointestinal reactions, and other side effects, limiting its wide range of clinical applications. At present, a variety of formulations improve its clinical efficacy and reduce adverse reactions to a certain extent. It may be more effective to modify the sinomenine to increase its stability from the viewpoint of pharmacochemistry. In addition, sinomenine has a chemical structure somewhat similar to that of morphine, but it is not addictive. Research on the relationship between drug addiction and the structure and activity of sinomenine may lead to the discovery of highly effective and low-toxicity natural drugs.


Sinomenine Rheumatism Arrhythmia Histamine release Morphine 


  1. 1.
    Xiao PG. Chinese Academy of Medical Sciences Institute of Chinese medicine. Traditional Chinese medicine zhi. People’s Health Publishing House, China; 1959.Google Scholar
  2. 2.
    Jiangsu New School of Medicine. Traditional Chinese medicine dictionary (volume 1). Shanghai: Shanghai Science and Technology Press; 1982. p. 1234.Google Scholar
  3. 3.
    Wang XL, Wen PH, Feng LM. Optimization of extraction technology of Sinomenine. Chin Trad Med. 1997;28(4):247–9.Google Scholar
  4. 4.
    Pan WJ, Li XN, Zhang ZT, et al. Extraction of sinomenine from Cynanchum paniculata by ultrasonic method. Nat Prod Res Dev. 2003;15(2):127–9.Google Scholar
  5. 5.
    Zhang MF, Zhao Y, Jiang KY, Han L, Lu XY, et al. Comparative pharmacokinetics study of sinomenine in rats after oral administration of sinomenine monomer and Sinomenium acutum extract. Molecules. 2014;19:12065–77.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Personalised recommendations