Potassium Dehydroandrographolide Succinate and Potassium Sodium Dehydroandrographolide Succinate

  • Yu Yan
  • Lian-Hua Fang
  • Guan-Hua DuEmail author


Potassium dehydroandrographolide succinate and potassium sodium dehydroandrographolide succinate are derivatives of andrographolide, which is the diterpene lactone compounds extracted from Andrographis paniculata (Burm. F) Nees. Andrographolide has effects on anti-inflammatory, antibacterial, antivirus, antitumor, immune regulation, treatment of cardiovascular-cerebrovascular diseases, and protection of liver and gallbladder but is unable to satisfy the clinical requirement due to the poor water solubility. Potassium dehydroandrographolide succinate and potassium sodium dehydroandrographolide succinate have a good effect in the wide clinical application; there is no need for skin test. However adverse reaction occurs due to its instability in the solution. Therefore, the researchers still need to study and develop preparation which is more safe, reliable, stable, and convenient to use to meet the clinical requirements.


Andrographolide Diterpene lactone Anti-inflammatory Antibacterial 


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© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug ScreeningCentre for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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