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Potassium Dehydroandrographolide Succinate and Potassium Sodium Dehydroandrographolide Succinate

  • Yu Yan
  • Lian-Hua Fang
  • Guan-Hua DuEmail author
Chapter

Abstract

Potassium dehydroandrographolide succinate and potassium sodium dehydroandrographolide succinate are derivatives of andrographolide, which is the diterpene lactone compounds extracted from Andrographis paniculata (Burm. F) Nees. Andrographolide has effects on anti-inflammatory, antibacterial, antivirus, antitumor, immune regulation, treatment of cardiovascular-cerebrovascular diseases, and protection of liver and gallbladder but is unable to satisfy the clinical requirement due to the poor water solubility. Potassium dehydroandrographolide succinate and potassium sodium dehydroandrographolide succinate have a good effect in the wide clinical application; there is no need for skin test. However adverse reaction occurs due to its instability in the solution. Therefore, the researchers still need to study and develop preparation which is more safe, reliable, stable, and convenient to use to meet the clinical requirements.

Keywords

Andrographolide Diterpene lactone Anti-inflammatory Antibacterial 

References

  1. 1.
    Andrographolide Research Team of Department of Pharmaceutical chemistry of Traditional Chinese medicine research institute of sichuan province. Research of dehydration paniculta lactone succinate half ester single potassium and its injection. Chin Herb Med Commun. 1978;8:1.Google Scholar
  2. 2.
    Xu R, Xu XL. Progress of clinical application of potassium dehydroandrographolide succinate injection. Chengdu Med J. 2005;31(4):278–80.Google Scholar
  3. 3.
    James RJ, Rui HL, Bud CT. Andrographolide derivatives to treat viral infections. USA: WO2006101537A2, 2006-09-28.Google Scholar
  4. 4.
    Zhang YT, Zhang ZJ, Sun YH. A study on the interaction of the DAS-K with bovine serum albumin by on-line ultrafiltration and chemiluminescence. Chin J Chem. 2004;24(12):1777–83.CrossRefGoogle Scholar
  5. 5.
    Kong QF, Deng YW, Pan XF. The clinical application and adverse reactions of potassium dehydroandrographolide succinate. Chin Pharm. 2006;9(8):765–6.Google Scholar
  6. 6.
    Liang JC. The clinical application of potassium sodium dehydroandrographolide succinate [J]. Chin Med Abstr: Intern Med. 2006;27(5):435–6.Google Scholar
  7. 7.
    Yan SY, Wang LF, Lv AQ. The clinical application of potassium dehydroandrographolide succinate injection. Chin Pharm Aff. 2005;19(5):311–2.Google Scholar
  8. 8.
    Cheng F. The adverse reaction and safety analysis of potassium sodium dehydroandrographolide succinate. Chin J Clin Rational Drug Use. 2015;8(11):96–7.Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug ScreeningCentre for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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