Oleanolic acid is extracted from Olea europaea, which is an important triterpenoid. Oleanolic acid aids in liver protection, especially increasing the amount of metallothionein and preventing glutathione emptying, and has antimicrobial and antiviral effects. Further, oleanolic acid exerts anticancer, anti-inflammatory, anti-HIV infection, hypoglycemic, and other functions. However, the poor bioavailability limited its application range. In the history of oleanolic acid’s R&D, balancing the bioavailability and the pharmacological activity in the process of drug preparation is the key to the further development of new drugs.
KeywordsOleanolic acid Triterpenoid Liver protection Bioavailability
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