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Oleanolic Acid

  • Qi-Meng Zhou
  • Guan-Hua DuEmail author
Chapter

Abstract

Oleanolic acid is extracted from Olea europaea, which is an important triterpenoid. Oleanolic acid aids in liver protection, especially increasing the amount of metallothionein and preventing glutathione emptying, and has antimicrobial and antiviral effects. Further, oleanolic acid exerts anticancer, anti-inflammatory, anti-HIV infection, hypoglycemic, and other functions. However, the poor bioavailability limited its application range. In the history of oleanolic acid’s R&D, balancing the bioavailability and the pharmacological activity in the process of drug preparation is the key to the further development of new drugs.

Keywords

Oleanolic acid Triterpenoid Liver protection Bioavailability 

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Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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