• Li Gao
  • Li-Da Du
  • Xue-Mei Qin
  • Jin-Hua Wang
  • Guan-Hua DuEmail author


Matrine is an alkaloid extracted by organic solvents from the dry roots, plants, and fruits of kushen (Sophora flavescens Ait). Matrine has significant effects of negative frequency and positive inotropic action, achieving the role of an antiarrhythmic. Moreover, matrine has an inhibitory effect on tumor cells by inhibiting growth and proliferation and inducing apoptosis. In the clinical setting, matrine injection was used for chronic active hepatitis, and a suppository was used for trichomoniasis or Candida vaginitis and chronic cervicitis. Improvements in the modern formulation of matrine can improve its clinical application.


Matrine Alkaloid Antiarrhythmic Anti-tumor 


  1. 1.
    Qian XZ. Color illustrations of Chinese Materia Medica. Beijing: People’s Medical Publishing House; 2003.Google Scholar
  2. 2.
    Editorial Committee of Chinese flora of Chinese Academy of Sciences. Flora of China. Beijing: Science Press; 2004.Google Scholar
  3. 3.
    Pharmacopoeia Commission of the Ministry of health of the People’s Republic of China. Pharmacopoeia of the People’s Republic of China. Beijing: Chemical Industry Press; 2015. p. 2015.Google Scholar
  4. 4.
    Zhang JT, Wang W, Duan ZH. Progress of research and application of matrine-type alkaloids. Prog Mod Biomed. 2007;7(3):451–4.Google Scholar
  5. 5.
    Zhao P, Zhang YJ, Yamamoto H, et al. Recent advance on the chemistry, bioactivity and biosynthesis of prenylated flavonoids from sophora flavecens. Nat Prod Res Dev. 2006;16(2):172–8.Google Scholar
  6. 6.
    Zhang LH, Chen BE, Pan MJ. Research progress on pharmacological action of matrine. Chin Tradit Herb Drug. 2009;40(6):1000–3.Google Scholar
  7. 7.
    Wang Y, Peng CH, Zhang GP. Study on invasion and metastasis related factors in differentiation of SMMC-7721 cells induced by matrine. J Chin Med Mater. 2003;26(8):566–9.Google Scholar
  8. 8.
    Huang J, Chen KJ, Zhang W. Effect of matrine on inhibiting proliferation and inducing apoptosis of human intestinum crassum carcinoma HT29 cells. Chin Tradit Herb Drug. 2007;38(8):1210–4.Google Scholar
  9. 9.
    Jiang HZ. Advances in pharmacological effects and preparation methods of matrine and oxymatrine. Pract Clin J Integr Tradit Chin West Med. 2007;7(1):89–90.Google Scholar
  10. 10.
    Qu ZP, Cui J, Harata-Lee Y, et al. Identification of candidate anti-cancer molecular mechanisms of compound kushen injection using functional genomics. Oncotarget. 2016;7(40):66003–19.PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  • Li Gao
    • 1
  • Li-Da Du
    • 2
  • Xue-Mei Qin
    • 1
  • Jin-Hua Wang
    • 3
  • Guan-Hua Du
    • 3
    Email author
  1. 1.Modern Research Center for Traditional Chinese MedicineShanxi UniversityShanxiChina
  2. 2.School of Biomedical ScienceThe Chinese University of Hong KongHong KongChina
  3. 3.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Personalised recommendations