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Matrine

  • Li Gao
  • Li-Da Du
  • Xue-Mei Qin
  • Jin-Hua Wang
  • Guan-Hua DuEmail author
Chapter

Abstract

Matrine is an alkaloid extracted by organic solvents from the dry roots, plants, and fruits of kushen (Sophora flavescens Ait). Matrine has significant effects of negative frequency and positive inotropic action, achieving the role of an antiarrhythmic. Moreover, matrine has an inhibitory effect on tumor cells by inhibiting growth and proliferation and inducing apoptosis. In the clinical setting, matrine injection was used for chronic active hepatitis, and a suppository was used for trichomoniasis or Candida vaginitis and chronic cervicitis. Improvements in the modern formulation of matrine can improve its clinical application.

Keywords

Matrine Alkaloid Antiarrhythmic Anti-tumor 

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Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  • Li Gao
    • 1
  • Li-Da Du
    • 2
  • Xue-Mei Qin
    • 1
  • Jin-Hua Wang
    • 3
  • Guan-Hua Du
    • 3
    Email author
  1. 1.Modern Research Center for Traditional Chinese MedicineShanxi UniversityShanxiChina
  2. 2.School of Biomedical ScienceThe Chinese University of Hong KongHong KongChina
  3. 3.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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