Advertisement

Dicoumarin

  • Xiao Cheng
  • Yue-Hua Wang
  • Guan-Hua DuEmail author
Chapter

Abstract

The plants containing dicoumarol mainly include red carnation grass, rotten alfalfa, rotten white vanilla rhinoceros, and other plants in Leguminosae. Dicoumarin, a coumarin derivative, is an oral anticoagulant drug, and its common mechanism is to inhibit synthesis of the coagulation factor in the liver. There are many coumarin derivatives, and the most common clinical drug is warfarin, which is applicable to long-term maintenance of anticoagulant. The most serious adverse reaction of warfarin is bleeding, which can be against by vitamin K. Up till now, warfarin is more reliable with more clinical experience and will be an important oral anticoagulant in the next few years.

Keywords

Dicoumarin Purple alfalfa Dicoumarol Bishydroxycoumarin 

References

  1. 1.
    Petit DW, Berne CJ. Dicumarol. Med Prog. 1947;67(1):40–4.Google Scholar
  2. 2.
    Aggeler PM. Heparin and dicumarol-anticoagulants: their prophylactic and therapeutic uses. Cal West Med. 1946;64(2):71–7.PubMedPubMedCentralGoogle Scholar
  3. 3.
    Shen D-S, Liu X-F, Yang G-Z. Synthesis of coumarin in anticoagulant and its analogues. J Appl Chem. 2005;22(10):1158–60.Google Scholar
  4. 4.
    Li J, Hou Z, Chen G. Synthesis, antibacterial activities, and theoretical studies of dicoumarols. Org Biomol Chem. 2014;12:5528–35.CrossRefGoogle Scholar
  5. 5.
    Dong J, Liu Y. Advances and clinical application of anticoagulant drugs. Chi J Geriatr Heart Brain Vessel Dis. 2013;15(12):1333–5.Google Scholar
  6. 6.
    Liu Y, Jan X. Antithrombotic treatment of atrial fibrillation. Ther Adv Cardiovasc Dis. 2010;31(2):185–9.Google Scholar
  7. 7.
    Wang M, Shi L, Gao M. Research status of anticoagulation therapy in patients with atrial fibrillation. Chin J Clinicians. 2015;9(6):980–4.Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical Screening, Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Personalised recommendations