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Brucine

  • Wan Li
  • Cui Yang
  • Guan-Hua DuEmail author
Chapter

Abstract

Brucine is extracted from the dry and mature seeds of Loganiaceae Evergreen tree plants including Strychnos nux-vomica L. and Strychnos pierriana A.W. Hill. Brucine has many pharmacological effects, including analgesic, anti-tumor, anti-pathogen, anti-inflammatory, and antibacterial effects and regulation of the immune system. In clinical practice, brucine is used as compatibility prescription or compound medicine in treating rheumatism, rheumatoid arthritis, stroke hemiplegia, dementia, retinopathy, and orthopedic and other surgical diseases. However, the toxicity of brucine limits its wide usage in the clinic. Therefore, studies of brucine on increasing its efficiency and decreasing its toxicity will improve the safety of its clinical use.

Keywords

Brucine Analgesic effects Rheumatism Toxicity 

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Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Yunnan Minzu UniversityYunnanChina

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