• Wan Li
  • Cui Yang
  • Guan-Hua DuEmail author


Brucine is extracted from the dry and mature seeds of Loganiaceae Evergreen tree plants including Strychnos nux-vomica L. and Strychnos pierriana A.W. Hill. Brucine has many pharmacological effects, including analgesic, anti-tumor, anti-pathogen, anti-inflammatory, and antibacterial effects and regulation of the immune system. In clinical practice, brucine is used as compatibility prescription or compound medicine in treating rheumatism, rheumatoid arthritis, stroke hemiplegia, dementia, retinopathy, and orthopedic and other surgical diseases. However, the toxicity of brucine limits its wide usage in the clinic. Therefore, studies of brucine on increasing its efficiency and decreasing its toxicity will improve the safety of its clinical use.


Brucine Analgesic effects Rheumatism Toxicity 


  1. 1.
    Xu JH, et al. Advances in studies on brucine. Chin J New Drugs. 2009;18(3):213–21.Google Scholar
  2. 2.
    An analysis of prepared TCM medicine containing Maqianzi in Chinese pharmacopoeia 2010 edition. Clin J Chin Med. 2014;6(23):9–10.Google Scholar
  3. 3.
    Zhao YL, et al. Research progress on pharmacokinetics of Strychnos nux-vomica and its preparation. Chin Tradit Herb Drug. 2015;46(11):1710–4.Google Scholar
  4. 4.
    Zhao LM, et al. Anti-tumor effect of brucine. Chin J Cancer Prev Treat. 2013;20(11):877–9.Google Scholar
  5. 5.
    Li XX, et al. Advances in studies on anti – tumor and attenuated efficacy of brucine. Guid China Med. 2013;11(20):486–8.Google Scholar
  6. 6.
    Tang DJ, et al. Comparative study on the pharmacodynamic effects on anti-inflammation and analgesia by brucine, semen strychnine and jiu-fen san. Inf Tradit Chin Med. 2014;4:1–3.Google Scholar
  7. 7.
    Qin JM, et al. The effect of brucine on hepatocellular carcinoma cell lines in vitro. Chin J Gen Surg. 2011;26(3):219–21.Google Scholar
  8. 8.
    Qin XS, et al. Study on the inhibitory effect of Chinese herbal extract on human immunodeficiency virus reverse transcriptase. Acta Acad Med Sinicae. 1990;12(6):391–5.Google Scholar
  9. 9.
    Zhu HX, et al. Discussion on the clinical application of Chinese herbal medicine brucine. Heilongjiang J Tradit Chin Med. 2008;37(3):54.Google Scholar
  10. 10.
    Lin CS, et al. Pharmacological study and clinical application of brucine. Tradit Chin Drug Res Clin Pharmacol. 2006;17(2):158–60.Google Scholar

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© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Yunnan Minzu UniversityYunnanChina

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