• Xiao-Bo Wang
  • Li-Da Du
  • Shu-Mei Wang
  • Guan-Hua DuEmail author


Vanillin is extracted from gastrodin and has been used in the treatment of epilepsy. Vanillin is known as one of the first synthetic spices. It can be used as intermediate for the synthesis of a variety of drugs, such as berberine and antihypertensive drug L-methyldopa, methoxy-pyrimidine, and heart disease drug papaverine. It has an antiepileptic and anticonvulsion effect and antibacterial action ability. As an important pharmaceutical intermediate, vanillin was used in the production of drugs. The main methods used for the synthesis of vanillin are nitrosation and glyoxylic acid method. These stable and high-yield processes would promote the development direction of vanillin.


Gastrodin Epilepsy Synthetic 


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Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  • Xiao-Bo Wang
    • 1
  • Li-Da Du
    • 2
  • Shu-Mei Wang
    • 1
  • Guan-Hua Du
    • 3
    Email author
  1. 1.Guangdong Pharmaceutical UniversityGuangdongChina
  2. 2.School of Biomedical SciencesChinese University of Hong KongHong KongChina
  3. 3.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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