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Ginkgolide B

  • Wen Zhang
  • Qi-Meng Zhou
  • Guan-Hua DuEmail author
Chapter

Abstract

Ginkgolide B belongs to families of ginkgo diterpene lipids, which are terpenes extracted from Ginkgo biloba. Ginkgolide B is both the platelet-activating factor (PAF) receptor antagonist and a nonspecific central nervous glycine receptor antagonist which can upregulate BDNF and inhibits the release of intracellular calcium ion and NO. Due to the complexity of its structure, its solubility and bioavailability are the most important factors affecting druggability. With the further study, this compound will be used in clinical better.

Keywords

Ginkgolide B Ginkgo biloba PAFR antagonist Glycine receptor antagonist 

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Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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