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Caffeine

  • Lin Wang
  • Li-Da Du
  • Guan-Hua DuEmail author
Chapter

Abstract

Caffeine is a kind of xanthine alkaloid and mainly found in coffee, tea, Paraguay Holly (Mate), and the fruit or leaf taken from guarana. Caffeine shows the function of dispelling fatigue and exciting nerve. The commonly used clinical preparations include caffeine sodium benzoate and ergotamine caffeine. The adverse reactions include nausea, vomiting, abdominal pain, and fatigue. Overdose of caffeine will cause damage to the human body. Due to addiction at high dose, caffeine is included in the scope of controlled psychotropic drugs. Caffeine is mainly metabolized in the liver, and only 1–5% of it is excreted as metabolites through urine. Theobromine is the main active metabolite of caffeine and reported to cause activities in the cardiovascular system.

Keywords

Coffee Alkaloid Addiction 

References

  1. 1.
    Yu-guan Z, Le S, Li X, et al. Caffeine in acute or chronic pain control and its possible mechanism. J Chin Acad Med Sci. 2014;6:697–700.Google Scholar
  2. 2.
    Chao-ran Y, Zhong-qing W. The pharmacological effects and application of caffeine. J Med Grad Stud. 2005;18(3):270–2.Google Scholar
  3. 3.
    Jia-bin H, Jing C, Wang J-k, et al. Progress in caffeine preparation methods. Chem Ind Vertical Horizontal. 2003;17(3):13–6.Google Scholar
  4. 4.
    Spriet LL. Exercise and sport performance with low doses of caffeine. Sports Med. 2014;44(2):S175–84.CrossRefGoogle Scholar
  5. 5.
    Hai-xia L, Rong C, Dan Z. Progress in the synthesis and pharmacological effects of caffeine. Pharm J West Chin. 2011;2(2):182–7.Google Scholar
  6. 6.
    Pohanka M. The perspective of caffeine and caffeine derived compounds in therapy. Bratisl Lek Listy. 2015;116(9):520–30.PubMedGoogle Scholar
  7. 7.
    Ying C. Reevaluation of caffeine as a central stimulant. Foreign Med Physiol Pathol Sci Clin Pathol. 1997;4:375–8.Google Scholar
  8. 8.
    Yao C, Hong-hao Z. The research progress of caffeine metabolism and its application. Prog Physiol Sci. 2010;41(4):256–60.Google Scholar
  9. 9.
    Jian-liang F, Yu L. Comparison between imitrex injection and ergotamine caffeine tablets in the treatment of migraine. Chin J New Drugs Clin Remedies. 1999;2:82–4.Google Scholar
  10. 10.
    D’Ambrosio SM. Evaluation of the genotoxicity data on caffeine. Regul Toxicol Pharmacol. 1994;19(3):243–81.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.School of Biomedical SciencesChinese University of Hong KongHong KongChina

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