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Tetrandrine

  • Huan Yang
  • Yue-Hua Wang
  • Guan-Hua Du
Chapter

Abstract

Tetrandrine (Tet) is a dibenzyl isoquinoline alkaloid, which is extracted from the root of Stephania tetrandra S. Moore (Fěn Fánɡ Jǐ) of Menispermaceae. Tetrandrine has strong biological effects on the cardiovascular diseases, fibrosis, tumors, portal vein and pulmonary hypertension, liver diseases, and immunological diseases. Current researches showed that tetrandrine is superior to conventional therapies in clinical treatment of silicosis. Other pharmacological effects of tetrandrine are still under research. As a traditional Chinese calcium antagonist, tetrandrine has significant effects on cardiovascular and inflammatory diseases with relatively fewer side effects, which grants it great potential for further explorations and clinical applications.

Keywords

Tetrandrine Alkaloid Cardiovascular diseases Clinical applications 

References

  1. 1.
    National Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China (volume 1). Beijing: China Medical Science and Technology Press; 2015. p. 148–9.Google Scholar
  2. 2.
    Zhen P. Research progress of tetrandrine. J Med Res. 2004;33(8):79–82.Google Scholar
  3. 3.
    Zhang XH. Study on the identification and clinical application of Stephania tetrandra S. Moore and Radix Aristolochiae Fangchi. Chin Mod Med. 2015;22(24):111–3.Google Scholar
  4. 4.
    Wang H, Luo SD, Cai HS. Pharmacological research progress of tetrandrine. Chin J Pharm. 2000;35(12):800–2.Google Scholar
  5. 5.
    King VF, Garcia ML, Himmel D. Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin. J Biol Chem. 1988;263:2238–44.PubMedGoogle Scholar
  6. 6.
    Liu YQ, Karpinski E, Rao MR. Tetrandrine: a novel calcium channel antagonist inhibits type I calcium channels in neuroblastoma cells. Neuropharmacology. 1991;30(12A):1325–31.CrossRefGoogle Scholar
  7. 7.
    Wang ZR. Research progress on pharmacological action of tetrandrine. Chin Pharmacol Bull. 2000;16(5):488–92.Google Scholar
  8. 8.
    Li DG, Liu YL, Lu HM, Jiang ZM, Xu QF. Effects of tetrandrine on mitochondria in rats with hepatic fibrosis. Chin J Dig. 1994;14(6):339–42.Google Scholar
  9. 9.
    Chen YJ. Potenital role of tetrandrine in cancer therapy. Acta Pharmacol Sin. 2002;23(12):1102–6.PubMedGoogle Scholar
  10. 10.
    Kwan CY. Traditional herbal medicine research with special reference to tetrandirne and related bis-benzylisoquinoline alkaloids: a preface to this special issue on herbal drugs. Acta Pharmacol Sin. 2002;23(12):I.PubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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