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Protocatechualdehyde

  • Yue-Hua Wang
  • Wei-Han Li
  • Guan-Hua Du
Chapter

Abstract

Protocatechualdehyde is a kind of phenolic acid compound extracted from roots of the common traditional Chinese medicine Salvia miltiorrhiza. Protocatechualdehyde is an important pharmaceutical intermediate, which could be used to synthesize many kinds of antibiotics and anti-inflammatory drugs. Protocatechualdehyde has wide pharmacological activities including anti-atherosclerosis, myocardial protection, antithrombosis, neuroprotection, antisepsis, antiviral, and anti-fibrosis. In clinical therapy, it is used to treat coronary heart disease, chest tightness, angina, and so on.

Keywords

Protocatechualdehyde Catechol formaldehyde Coronary heart disease Chest tightness Angina 

References

  1. 1.
    Yang YL. Study on Sijiqing. Jiangsu Med. 1976;2:59–61.Google Scholar
  2. 2.
    Jiangsu New Medical College of pharmacology group and Chinese herbal medicine group. Preliminary analysis of Sijiqing, Salvia miltiorrhiza, Mao Dongqing, et al. on the coronary sinus flow, myocardial oxygen consumption. Jiangsu Med. 1977;4:19–21.Google Scholar
  3. 3.
    Zhang KZ, Zou YB, Lu WJ. Guanxinning (protocatechuic aldehyde) treatment of angina pectoris of coronary heart disease: a clinical observation of 27 cases. Jiangsu Med. 1978;1:8–9.Google Scholar
  4. 4.
    Yao JY, Chen ZJ, Shao ZG, et al. Isolation and identification of the effective components of protocatechuic aldehyde in Salvia miltiorrhiza Bunge. J Nanjing Col Pharm. 1979;1:74–6.Google Scholar
  5. 5.
    Yang YL, Cao JY, Xu XQ, et al. Study on distribution, excretion and toxicity of protocatechuic aldehyde in animals. Jiangsu Med. 197(10):16–9.Google Scholar
  6. 6.
    Yang YL, Wu YN, Duan WY. Preliminary study on the antiplatelet effect of protocatechuic aldehyde. J Nantong Med Coll. 1981;2:15–6.Google Scholar
  7. 7.
    Shi L, Wu CQ, Yang YL, et al. Effects of protocatechuic aldehyde on platelet aggregation and platelet cAMP content. J Suzhou Med Coll. 1982;2:1–6.Google Scholar
  8. 8.
    Shen LH, Wang BY, Wang CQ, et al. Experimental study on the effect of protocatechuic aldehyde on microcirculation in rats. J Microcirc. 2002;12(2):12–4.Google Scholar
  9. 9.
    Liu M, Xia XH, Zhang ZM, et al. Comparative study on antioxidant activity of Danshensu, protocatechuic aldehyde, caffeic acid and salvianolic acid B in vitro. Chin Herb Med. 2009;32(2):265–7.Google Scholar
  10. 10.
    Zhang CY, Guo LL, Wang Z. Pharmacological research progress of protocatechuic aldehyde. Chin J Exp Tradit Med Formul. 2013;19(23):338–42.Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical Screening, Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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