Advertisement

Papaverine

  • De Kang
  • Gui-Fen Qiang
  • Li-Da Du
  • Guan-Hua DuEmail author
Chapter

Abstract

Papaverine is mainly extracted from the mature capsule shell of Papaveraceae poppy. As a vasodilator, papaverine is a nonspecific antispasmodic drug of smooth muscle, used for the treatment of ischemia caused by cerebral, cardiac, and peripheral vascular spasm, as well as visceral spasm of the kidney, gallbladder, or gastrointestinal tract. However, high dose of papaverine can cause hypotension and tachycardia without effect on the central nervous system. As an old variety recorded in pharmacopoeia, papaverine hydrochloride has demonstrated its clinical efficacy and safety after its clinical usage for decades. To avoid the serious adverse reaction caused by intravenous injection, the improved dosage forms were developed for the rational administration of papaverine hydrochloride to benefit the patients.

Keywords

Papaverine Papaveraceae poppy Vasodilator Ischemia 

References

  1. 1.
    Elad D, Ginsburg D. The synthesis of papaverine. Bull Narc (UNDOC). 1952;3:27–34.Google Scholar
  2. 2.
    Mao HK. Papaverine hydrochloride (synthesis) appraisal meeting. Pharm Ind. 1981;3:45.Google Scholar
  3. 3.
    Merck & Co. Merck’s 1907 Index.Google Scholar
  4. 4.
    Goldschmiedt. Monatsch. 1883;4:704.CrossRefGoogle Scholar
  5. 5.
    Pal J. Das Papaverine als Gefässmittel und Anaestheticum. Dtsch Med Wochenschr. 1914;40:164.CrossRefGoogle Scholar
  6. 6.
    Macht DI. A pharmacologic and clinical study of papaverine. Ann Int Med. 1916;17:786.CrossRefGoogle Scholar
  7. 7.
    Meyer JS, Gotoh F, Gilroy J, Nara N. Improvement in brain oxygenation and clinical improvement in patients with strokes treated with papaverine hydrochloride. JAMA. 1965;194(9):957–61.CrossRefGoogle Scholar
  8. 8.
    Wang C, Yuan WJ, Wang YX. Analysis on 70 cases about no addiction of papaverine hydrochloride. Chin Hosp Pharm J. 1982;2:17–9.Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical Screening, Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.School of Biomedical SciencesChinese University of Hong KongHong KongChina

Personalised recommendations