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Ligustrazine

  • Guo-Rong He
  • Shou-bao Wang
  • Guan-Hua DuEmail author
Chapter

Abstract

Ligustrazine is extracted from chuanxiong 川芎 (Ligusticum chuanxiong Hort; L. wallichii), which is the most important alkaloid in chuanxiong. Studies have demonstrated that ligustrazine is effective at promoting blood flow, the circulation of Qi, and the removal of blood stasis, so it has been extensively used to treat ischemic cardiovascular and cerebrovascular diseases, such as atherosclerosis, hypertension, and stroke. Ligustrazine has also used to treat children with viral myocarditis, chronic renal failure, hepatic fibrosis, portal hypertension, tumors, and diabetic nephropathy. Ligustrazine can relieve symptoms rapidly, and its effect is stable and lasting. It has good spread of the value in clinic. To decide the specificity of ligustrazine used in clinic, we carried out a large-sample, multicenter, randomized, double-blind, placebo-controlled trial, which provides evidences for the extensive use of ligustrazine in clinic.

Keywords

Ligustrazine Alkaloid Antiapoptosis Promoting blood circulation 

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Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug ScreeningCentre for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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