• Rui Zhao
  • Li-Da Du
  • Guan-Hua DuEmail author


Fructus Meliae Toosendan is a traditional Chinese medicine which is still used in internal medicine. Toosendanin is a tetracyclic triterpene compound extracted from fructus toosendan. The structure was identified in 1975. A synthetic strategy is put forth in 2009. It is an ascaridole agent and showed anti-botulinum, antibacterial, anticancer, and anti-inflammatory effects. It is also a neuromuscular blocking agent.


Toosendanin Tetracyclic triterpene compound Insecticide 


  1. 1.
    Chinese Academy of Medical Sciences. Zhong Yao Zhi. Beijing: People’s Medical Publishing House; 1961. p. 162–5.Google Scholar
  2. 2.
    Zhong CC, Xi JX. The structure of Toosendanin. Acta Chim Sin. 1975;33(1):35–47.Google Scholar
  3. 3.
    Nakai Y, Tepp WH. Function-oriented synthesis applied to the anti-botulinum natural product toosendanin. Bioorg Med Chem. 2009;17(3):1152–7.CrossRefGoogle Scholar
  4. 4.
    Shi YL, Wei NS. Toosendanin- a presynaptic neuromuscular junction transfer blocking agent. Acta Physiol Sin. 1980;32(3):293–7.Google Scholar
  5. 5.
    Shi YL, Xu K. Botulinum resistant effect of toosendanin. Chin Sci Bull. 1983;28(14):885–7.Google Scholar
  6. 6.
    Shi YL, Wang WP. Biological effects of toosendanin, an active ingredient of herbal vermifuge in Chinese traditional medicine. Acta Physiol Sin. 2006;58(05):397–406.Google Scholar
  7. 7.
    Zhang X, Wang XL. The development of botanical insecticides- toosendanin. Acta Northwest Univ Agric Sin. 1993;21(1):1–5.Google Scholar
  8. 8.
    Shi YL, Wang WP. Toosendanin modifies K+-and Ca2+-channel activity and intracellular Ca2+ concentration. Prog Biochem Biophys. 2007;34(02):132–7.Google Scholar
  9. 9.
    Wang XJ, Liu YR. Review on anti-tumor effects and mechanisms of toosendanin. Sci Technol Eng. 2011;11(02):281–5.Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina
  2. 2.School of Biomedical SciencesChinese University of Hong KongHong KongChina
  3. 3.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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