• Xiao-Xiu Li
  • Li-Da Du
  • Guan-Hua DuEmail author


Osthole is derived from Umbelliferae and Rutaceae plants. It is a Chinese medicine which is used widely by traditional medicine doctors. Cnidium has been recorded in almost all of the pharmaceutical monograph. Osthole exhibits a variety of pharmacological effects including neuroprotective, osteogenic, immunomodulatory, anticancer, hepatoprotective, cardiovascular protective, and antimicrobial activities. It is expected to be used in the treatment of cardiovascular system, central nervous system, and immune system diseases. Further studies are needed to enrich the knowledge of the pharmacological effects and address the safety issues of osthole in order to develop this natural product and its derivatives as an agent for disease prevention and therapeutics in human.


Osthole Anticancer Neuroprotective Cardiovascular protective 


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© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Department of Pharmacology, Liaoning Key Laboratory of Behavior and Cognitive NeuroscienceShenyang Medical CollegeShenyangChina
  2. 2.School of Biomedical SciencesChinese University of Hong KongHong KongChina
  3. 3.Beijing Key Laboratory of Drug Targets Identification and Drug ScreeningCentre for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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