Cytisine is an alkaloid, which is isolated from Laburnum and Cytisus of the family Fabaceae. Cytisine has a similar chemical structure to that of nicotine, and it possesses selective binding affinity for neuronal nicotinic acetylcholine receptors, which is even superior to that of nicotine and many other agonists. In 1960s, cytisine was firstly used as a smoking cessation aid in Bulgaria. However, cytisine remains relatively unknown outside Eastern Europe, and further clinical studies for its long-term therapeutic effects are also essential.
KeywordsCytisine Alkaloid Nicotine Smoking cessation