• Xiao-Ming Zhu
  • Li-Da Du
  • Guan-Hua Du


Cytisine is an alkaloid, which is isolated from Laburnum and Cytisus of the family Fabaceae. Cytisine has a similar chemical structure to that of nicotine, and it possesses selective binding affinity for neuronal nicotinic acetylcholine receptors, which is even superior to that of nicotine and many other agonists. In 1960s, cytisine was firstly used as a smoking cessation aid in Bulgaria. However, cytisine remains relatively unknown outside Eastern Europe, and further clinical studies for its long-term therapeutic effects are also essential.


Cytisine Alkaloid Nicotine Smoking cessation 


  1. 1.
    Tutka P, Zatonski W. Cytisine for the treatment of nicotine addiction: from a molecule to therapeutic efficacy. Pharmacol Rep. 2006;58(6):777–98.PubMedGoogle Scholar
  2. 2.
    Walker N, Howe C, Glover M, McRobbie H, Barnes J, Nosa V, Parag V, Bassett B, Bullen C. Cytisine versus nicotine for smoking cessation. N Engl J Med. 2014;371(25):2353–62.CrossRefGoogle Scholar

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© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Quality Research in Chinese MedicineMacau University of Science and TechnologyTaipa, MacauChina
  2. 2.School of Biomedical SciencesChinese University of Hong KongHong KongChina
  3. 3.Beijing Key Laboratory of Drug Targets Identification and Drug ScreeningCentre for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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