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Santonin

  • De-Zhi Yang
  • Li-Da Du
  • Yang Lu
Chapter

Abstract

Santonin is a lactone compound extracted from the flower bud of Artemisia cina Berg in Compositae, crown daisy chrysanthemum or other plants in Artemisia. It has been recorded in ancient China. Its English name is santonica wormseed. There are more than 100 plus in sagebrush, in which about 30 plus live in China, and parts of them can be used medicinally. Santonin has been used for a long time as a kind of deworming drug. Santonin has obvious central nervous system toxicity. A small amount can cause colour deficiency, and a large amount can cause epileptiform, excessive excitement turning into severe repression, and even coma. Santonin is a highly toxic substance. Children’s lethal dose is 0.15 g; adults’ lethal dose is about 1 g. Santonin has already been phased out for the toxicity.

Keywords

Santonin Wormseed Lactone Deworming Toxicity 

References

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Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Polymorphic Drugs, Research Center of Polymorphic Drugs, Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.School of Biomedical SciencesChinese University of Hong KongHong KongChina

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