Endoscopic Treatment of Esophageal Varices: Takase Method

  • Fumio Chikamori
  • Yasuhiro Takase


Endoscopic injection sclerotherapy (EIS), using the Takase method is now widely accepted and used to treat esophageal varices.

Intravariceal injection of 5% ethanolamine oleate with contrast iopamidol embolizes the varices along with blood supply routes. Portal hemodynamics and liver function are not affected after EIS. The recurrence rates of esophageal varices at 2 years after EIS with complete and incomplete embolization of blood supply routes were 7% and 70%, respectively (p < 0.05). Because of this result, we consider the complete embolization of varices and their blood supply routes with EIS to be the first-choice treatment for esophageal varices to diminish the variceal recurrence rate.


Endoscopic injection sclerotherapy Esophagogastric varices Blood supply route 5% Ethanolamine oleate with iopamidol 



I thank Dr. Niranjan Sharma PhD, Mornington Health Center, Dunedin, New Zealand, for helpful comments.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Fumio Chikamori
    • 1
  • Yasuhiro Takase
    • 2
  1. 1.Department of SurgeryTano HospitalKochiJapan
  2. 2.Department of SurgeryTsukuba Soai HospitalTsukubaJapan

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