Thermophiles vs. Psychrophiles: Cues from Microbes for Sustainable Industries

  • Monica SharmaEmail author


Though cellular architecture and functions show vast array of adaptive features to combat extreme temperature regime, enzymes are the key determinants of thermal adaption in both extremes of life, i.e., psychrophily or thermophily, as they drive the metabolism and cell cycle. Psychrophilic enzymes exhibit high specific activity at lower temperature range by disappearance of non-covalent stabilizing interactions (H bonding, hydrophobic interactions, salt bridges, etc.) and proline and arginine residues which cause improved flexibility (local/global) in conformation of enzymes. These enzymes have devised diverse ways to achieve the feat to live in extremity. Thermophilic enzymes work totally opposite to psychrophiles, i.e., by increasing proline number that causes proline isomerization which renders them to be more rigid and have higher arginine content which leads to increased salt bridge formation and extensive H bonding, etc. Oligomerization and heat shock proteins further give microbes stability against temperature.


Psychrophiles Thermophiles Oligomerization Proline isomerization 


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Biotechnology, School of Life SciencesBabasaheb Bhimrao Ambedkar University (A Central University)LucknowIndia

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