Glycoproteins of HHV-6A and HHV-6B

  • Huamin TangEmail author
  • Yasuko Mori
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1045)


Recently, human herpesvirus 6A and 6B (HHV-6A and HHV-6B) were classified into distinct species. Although these two viruses share many similarities, cell tropism is one of their striking differences, which is partially because of the difference in their entry machinery. Many glycoproteins of HHV-6A/B have been identified and analyzed in detail, especially in their functions during entry process into host cells. Some of these glycoproteins were unique to HHV-6A/B. The cellular factors associated with these viral glycoproteins (or glycoprotein complex) were also identified in recent years. Detailed interaction analyses were also conducted, which could partially prove the difference of entry machinery in these two viruses. Although there are still issues that should be addressed, all the knowledges that have been earned in recent years could not only help us to understand these viruses’ entry mechanism well but also would contribute to the development of the therapy and/or prophylaxis methods for HHV-6A/B-associated diseases.


HHV-6 Glycoprotein Tropism Entry CD46 CD134 


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of ImmunologyNanjing Medical UniversityNanjingChina
  2. 2.Division of Clinical Virology, Center for Infectious DiseasesKobe University Graduate School of MedicineKobeJapan

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