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Vaccine Development for Varicella-Zoster Virus

  • Tomohiko Sadaoka
  • Yasuko Mori
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1045)

Abstract

Varicella-zoster virus (VZV) is the first and only human herpesvirus for which a licensed live attenuated vaccine, vOka, has been developed. vOka has highly safe and effective profiles; however, worldwide herd immunity against VZV has not yet been established and it is far from eradication. Despite the successful reduction in the burden of VZV-related illness by the introduction of the vaccine, some concerns about vOka critically prevent worldwide acceptance and establishment of herd immunity, and difficulties in addressing these criticisms often relate to its ill-defined mechanism of attenuation. Advances in scientific technologies have been applied in the VZV research field and have contributed toward uncovering the mechanism of vOka attenuation as well as VZV biology at the molecular level. A subunit vaccine targeting single VZV glycoprotein, rationally designed based on the virological and immunological research, has great potential to improve the strategy for eradication of VZV infection in combination with vOka.

Keywords

Varicella-zoster virus Live attenuated vaccine Next-generation sequencing In vitro latency system VZV-specific cellular immunity Herpes zoster subunit vaccine 

Notes

Acknowledgment

The authors thank Dr. Daniel P. Depledge for helpful discussions and critical reading of the manuscript. This work was supported in part by the Japan Herpesvirus Infections Forum, the Takeda Science Foundation, the Japan Foundation for Pediatric Research, and Japan Society for the Promotion of Science (JSPS KAKENHI JP17K008858).

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Division of Clinical Virology, Center for Infectious DiseasesKobe University Graduate School of MedicineKobeJapan

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