Signal Transduction Pathways Associated with KSHV-Related Tumors

  • Tadashi Watanabe
  • Atsuko Sugimoto
  • Kohei Hosokawa
  • Masahiro FujimuroEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1045)


Signal transduction pathways play a key role in the regulation of cell growth, cell differentiation, cell survival, apoptosis, and immune responses. Bacterial and viral pathogens utilize the cell signal pathways by encoding their own proteins or noncoding RNAs to serve their survival and replication in infected cells. Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is classified as a rhadinovirus in the γ-herpesvirus subfamily and was the eighth human herpesvirus to be discovered from Kaposi’s sarcoma specimens. KSHV is closely associated with an endothelial cell malignancy, Kaposi’s sarcoma, and B-cell malignancies, primary effusion lymphoma, and multicentric Castleman’s disease. Recent studies have revealed that KSHV manipulates the cellular signaling pathways to achieve persistent infection, viral replication, cell proliferation, anti-apoptosis, and evasion of immune surveillance in infected cells. This chapter summarizes recent developments in our understanding of the molecular mechanisms used by KSHV to interact with the cell signaling machinery.


Akt Apoptosis Cell cycle IFN IRF KSHV MAPK NF-κB Notch p53 Signal transduction pathway Viral microRNA Viral noncoding RNA Wnt/β-catenin 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Tadashi Watanabe
    • 1
  • Atsuko Sugimoto
    • 1
  • Kohei Hosokawa
    • 1
  • Masahiro Fujimuro
    • 1
    Email author
  1. 1.Department of Cell BiologyKyoto Pharmaceutical UniversityKyotoJapan

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