Endophytic Fungi and Bioactive Metabolites Production: An Update

  • Ramesha Alurappa
  • Srinivas Chowdappa
  • Radhakrishnan Narayanaswamy
  • Uma Rani Sinniah
  • Sudipta Kumar Mohanty
  • Mallappa Kumara SwamyEmail author


Endophytic fungi are unique microbes that reside in the plant tissues and cause no harm or any symptoms of diseases. Although plants are the major source of modern drugs, there is a continuous search for new sources to obtain new lead molecules, with higher biological properties, for treating various diseases. Many plants are associated with several kinds of endophytic fungi capable of producing bioactive secondary metabolites. Thus, endophytic fungi can act as a reservoir of bioactive principles which are yet to be explored in detail. In addition, plant-endophytic fungal association stimulates plant growth, increase resistance towards phyto-pathogens, suppress the weed, and increase tolerance to abiotic and biotic stresses. In this chapter, various aspects of endophytic fungi including their symbiosis with plants, biological implications and important secondary metabolites production are discussed in detail. This information would certainly help to improve the pace of modern drug discovery.


Endophytes Symbiosis Bioactive compounds Metabolites Anticancer Antimicrobial 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Ramesha Alurappa
    • 1
  • Srinivas Chowdappa
    • 2
  • Radhakrishnan Narayanaswamy
    • 3
  • Uma Rani Sinniah
    • 4
  • Sudipta Kumar Mohanty
    • 1
  • Mallappa Kumara Swamy
    • 1
    • 4
    Email author
  1. 1.Padmashree Institute of Management and SciencesBengaluruIndia
  2. 2.Department of Microbiology and Biotechnology, Jnanabharathi CampusBangalore UniversityBengaluruIndia
  3. 3.Bio Incubator and Lab,Vel Tech Technology Incubator, Veltech Rangarajan Dr. Sagunthala R & D Institute of Science and TechnologyChennaiIndia
  4. 4.Department of Crop Science, Faculty of AgricultureUniversiti Putra Malaysia (UPM)SerdangMalaysia

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