Development and Functional Anatomy of the Spine and Spinal Cord

  • Hyun-Yoon Ko


Understanding the development and functional anatomy of the human spinal cord is a very important information for the management and rehabilitation of spinal cord injury patients as clinical medicine. Knowing the development of the spinal cord and other nervous systems, including the spine, dermatome and myotome formation through metamerism, allows us to better evaluate clinically and better understand the diseases or traumatic lesions that occur in spinal cord.


  1. Afifi AK, Bergman RA. Functional neuroanatomy: text and atlas. 2nd ed. New York: Lange Medical Books/McGraw-Hill; 2005.Google Scholar
  2. Armand J. The origin, course and termination of corticospinal fibers in various mammals. Prog Brain Res. 1982;57:329–60.CrossRefGoogle Scholar
  3. Barson AJ. The vertebral level of termination of the spinal cord during normal and abnormal development. J Anat. 1970;106:489–97.PubMedPubMedCentralGoogle Scholar
  4. Bican O, Minagar A, Pruitt AA. The spinal cord: a review of functional neuroanatomy. Neurol Clin. 2013;31:1–18.CrossRefGoogle Scholar
  5. Blumenfeld H. Neuroanatomy through clinical cases. 2nd ed. Sunderland: Sinauer Associates; 2010.Google Scholar
  6. Breig A, el-Nadi AF. Biomechanics of the cervical spinal cord. Relief of contact pressure on and overstretching of the spinal cord. Acta Radiol Diagn (Stockh). 1966;4:602–24.CrossRefGoogle Scholar
  7. Breig A, Turnbull I, Hassler O. Effects of mechanical stresses on the spinal cord in cervical spondylosis. A study on fresh cadaver material. J Neurosurg. 1966;25:45–56.CrossRefGoogle Scholar
  8. Campbell WW. DeJong’s the neurologic examination. 7th edn. New York: Wolters Kluwer Lippincott Williams & Wilkins; 1992.Google Scholar
  9. Cho TA. Spinal cord functional anatomy. Continuum (Minneap Minn). 2015;21:13–35.Google Scholar
  10. Clifton GL, Coggeshall RE, Vance WH, et al. Receptive fields of unmyelinated ventral root afferent fibres in the cat. J Physiol. 1976;256:573–600.CrossRefGoogle Scholar
  11. Clowry GJ, Moss JA, Clough RL. An immunohistochemical study of the development of sensorimotor components of the early fetal human spinal cord. J Anat. 2005;207:313–24.CrossRefGoogle Scholar
  12. Cole J, Weller R. Introduction to the clinical presentations of spinal cord disease from a pathophysiological perspective. In: Engler GL, Cole J, Merton WL, editors. Spinal cord diseases. Diagnosis and treatment. New York: Marcel Dekker, Inc.; 1998. p. 1–13.Google Scholar
  13. Copp AJ, Greene ND. Neural tube defects-disorders of neurulation and related embryologic processes. Wiley Interdiscip Rev Dev Biol. 2013;2:213–37.CrossRefGoogle Scholar
  14. Coppola AR. “Cruciate paralysis”: a complication of surgery. South Med J. 1973;66:684.Google Scholar
  15. Craw CH. The distribution of the nerve cells in the ventral columns of the spinal cord. J Comp Neurol. 1928;45:283–99.CrossRefGoogle Scholar
  16. d’Amato C. Pediatric spinal trauma: injuries in very young children. Clin Orthop Relat Res. 2005;432:34–40.CrossRefGoogle Scholar
  17. Dumitru D, Lang JE. Cruciate paralysis. Case report. J Neurosurg. 1986;65:108–10.CrossRefGoogle Scholar
  18. Durrant DH, True JM Myelopathy, Radiculopathy, and peripheral entrapment syndromes. Boca Raton: CRC Press; 2002.Google Scholar
  19. Elliott HC. Studies on the motor cells of the spinal cord, I. Distribution in the normal human cord. Am J Anat. 1942;70:95–117.CrossRefGoogle Scholar
  20. Etz CD, Kari FA, Mueller CS, et al. The collateral network concept: a reassessment of the anatomy of spinal cord perfusion. J Thorac Cardiovasc Surg. 2011;141:1020–8.CrossRefGoogle Scholar
  21. Greene ND, Vopp AJ. Neural tube defects. Annu Rev Neurosci. 2014;37:221–42.CrossRefGoogle Scholar
  22. Heines DE, Harkey HL, Al-Mefty O. The “subdural” space: a new look at an outdated concept. Neurosurgery. 1993;32:111–20.CrossRefGoogle Scholar
  23. Holmes A, Han ZH, Dang GT, et al. Changes in cervical canal spinal volume during in vitro flexion-extension. Spine (Phila Pa 1976). 1996;21:1313–9.CrossRefGoogle Scholar
  24. Hughes JT. In: Vinken PJ, Bruyn GW, Klawans HL, editors. Vascular diseases, part III. London: Elsevier; 1989.Google Scholar
  25. Huisman TA, Wagner MW, Bosemani T, et al. Pediatric spinal trauma. J Neuroimaging. 2015;25:337–53.CrossRefGoogle Scholar
  26. Kameyama T, Hashizume Y, Sobue G. Morphologic features of the normal human cadaveric spinal cord. Spine (Phila Pa 1976). 1996;21:1285–90.CrossRefGoogle Scholar
  27. Keegan JJ, Garrett FD. The segmental distribution of the cutaneous nerves in the limbs of man. Anat Rec. 1948;102:409–37.CrossRefGoogle Scholar
  28. Keller R, Shook D, Skoglund P. The forces that shape embryos: physical aspects of convergent extension by cell intercalation. Phys Biol. 2008;5:015007.CrossRefGoogle Scholar
  29. Kellgren JH. On the distribution of pain arising from deep somatic structures with charts of segmental pain areas. Clin Sci. 1939;4:35–46.Google Scholar
  30. Khanna G, El-Khoury GY. Imaging of cervical spine injuries of childhood. Skelet Radiol. 2007;36:477–94.CrossRefGoogle Scholar
  31. Ko HY, Park JH, Shin YB, et al. Gross quantitative measurements of spinal cord segments in human. Spinal Cord. 2004;42:35–40.CrossRefGoogle Scholar
  32. Lustrin ES, Karakas SP, Ortiz AO, et al. Pediatric cervical spine: normal anatomy and variants, and trauma. Radiographics. 2003;23:539–60.CrossRefGoogle Scholar
  33. Melissano G, Civilini E, Bertoglio L, et al. Angio-CT imaging of the spinal cord vascularisation: a pictorial essay. Eur J Vasc Endovasc Surg. 2010;39:436–40.CrossRefGoogle Scholar
  34. Melissano G, Bertoglio L, Rinaldi E, et al. An anatomical review of spinal cord blood supply. J Cardiovasc Surg (Torino). 2015;56:699–706.Google Scholar
  35. Moore KL, Dalley AF. Clinically oriented anatomy. 4th ed. Philadelphia: Lippincott Williams and Wilkins; 1999.Google Scholar
  36. Murthy NS, Maus TP, Behrns C. Intraforaminal location of the great anterior radiculomedullary artery (artery of Adamkiewicz): a retrospective review. Pain Med. 2010;11:1756–64.CrossRefGoogle Scholar
  37. Nijenhuis RJ, Mull M, Wilmink JT, et al. MR angiography of the great anterior radiculomedullary artery (Adamkiewicz artery) validated by digital subtraction angiography. AJNR Am J Neuroradiol. 2006;27:1565–72.PubMedGoogle Scholar
  38. Norenberg MD, Smith J, Marcillo A. The pathology of human spinal cord injury: defining the problems. J Neurotrauma. 2004;21:429–40.CrossRefGoogle Scholar
  39. Novy J, Carruzzo A, Maeder P, et al. Spinal cord ischemia. Arch Neurol. 2006;63:1113–20.CrossRefGoogle Scholar
  40. Nyberg G, Blomqvist A. The somatotopic organization of forelimb cutaneous nerves in the brachial dorsal horn: an anatomical study in the cat. J Comp Neurol. 1985;242:28–39.CrossRefGoogle Scholar
  41. O’rahilly R, Muller F. The two sites of fusion of the neural folds and the two neuropores in the human embryo. Teratology. 2002;65:162–70.CrossRefGoogle Scholar
  42. Patestas MA, Gartner LP. A textbook of neuroanatomy. Oxford: Blackwell Publishing; 2006.Google Scholar
  43. Rexed B. A cytoarchitectonic atlas of the spinal cord in the cat. J Comp Neurol. 1954;100:297–379.CrossRefGoogle Scholar
  44. Rexed B, Brodal A. The nucleus cervicalis lateralis: a spinocerebellar relay nucleus. J Neurophysiol. 1951;14:399–407.CrossRefGoogle Scholar
  45. Rubin MN, Rabinstein AA. Vascular diseases of the spinal cord. Neurol Clin. 2013;31:153–81.CrossRefGoogle Scholar
  46. Sadler TW. Embryology of neural tube development. Am J Med Genet C Semin Med Genet. 2005;135C:2–8.CrossRefGoogle Scholar
  47. Scharrer E. Capillaries and mitochondria in neutrophil. J Comp Neurol. 1945;83:237–43.CrossRefGoogle Scholar
  48. Sharrard WJW. The distribution of the permanent paralysis in the lower limb in poliomyelitis: a clinical and pathological study. J Bone Joint Surg. 1955;37:540–58.CrossRefGoogle Scholar
  49. ten Donkelaar HJ, Lammens M, Wesseling P, et al. Development and malformations of the human pyramidal tract. J Neurol. 2004;251:1429–42.CrossRefGoogle Scholar
  50. Tomlinson BE, Irving D, Rebeiz JJ. Total numbers of limb motor neurons in the human lumbosacral cord and an analysis of the accuracy of various sampling procedures. J Neurol Sci. 1973;20:313–27.CrossRefGoogle Scholar
  51. Turnbull IM, Brieg A, Hassler O. Blood supply of cervical spinal cord in man. A microangiographic cadaver study. J Neurosurg. 1966;24:951–65.CrossRefGoogle Scholar
  52. Vallstedt A, Kullander K. Dorsally derived spinal interneurons in locomotor circuits. Ann N Y Acad Sci. 2013;1279:32–42.CrossRefGoogle Scholar
  53. Vanderah TW, Gould DJ. Nolte’s the human brain. 6th ed. London: Elsevier; 2016.Google Scholar
  54. Watson C, Paxinos G, Kayalioglu G. The spinal cord. London: Academic; 2009.Google Scholar
  55. Weidenheim KM, Bodhireddy SR, Rashbaum WK, et al. Temporal and spatial expression of major myelin protein in the human fetal spinal cord during the second trimester. J Neuropathol Exp Neurol. 1996;55:734–45.CrossRefGoogle Scholar
  56. Zeman W, Innes JRM. Craigie’s neuroanatomy of the rat. New York: Academic; 1963.Google Scholar
  57. Zhang S, Wadhwa R, Haydel J, et al. Spine and spinal cord trauma: diagnosis and management. Neurol Clin. 2013;31:183–206.CrossRefGoogle Scholar

Suggested Reading

  1. Afifi AK, Bergman RA. Functional neuroanatomy: text and atlas. 2nd ed. New York: Lange Medical Books/McGraw-Hill; 2005.Google Scholar
  2. Altman J, Bayer SA. Development of the human spinal cord: an interpretation based on experimental studies. 1st ed. New York: Oxford University Press; 2001.Google Scholar
  3. Byrne TN, Benzel EC, Waxman SG. Diseases of the spine and spinal cord. Oxford: Oxford University Press; 2000.Google Scholar
  4. Crossman A, Neary D. Neuroanatomy: an illustrated colour test. 5th ed. Philadelphia: Elsevier; 2015.Google Scholar
  5. Fehlings MG, Vccaro AR, Roakye M, Rossignol S, Ditunno JF, Burns AS, editors. Essentials of spinal cord injury: basic research to clinical practice. New York: Thieme; 2013.Google Scholar
  6. Felten DL, O’Banion MK, Maida MS. Netter’s atlas of neuroscience. 3rd ed. London: Elsevier; 2016.Google Scholar
  7. Flint G, Rusbridge C, editors. Syringomyelia, a disorder of CSF circulation. London: Springer; 2014.Google Scholar
  8. Kirshblum S, Campagnolo DI, editors. Spinal cord medicine. 2nd ed. Philadelphia: Wolters Kluwer, Lippincott, Williams & Wilkins; 2011.Google Scholar
  9. Lin VW, editor. Spinal cord medicine. Principles and practice. 2nd ed. New York: Demos Medical; 2010.Google Scholar
  10. Mai JK, Paxinos G, editors. The human nervous system. 3rd ed. London: Elsevier; 2011.Google Scholar
  11. Mancall E. Gray’s clinical neuroanatomy: the anatomic basis for clinical neuroscience. Philadelphia: Elsevier; 2011.Google Scholar
  12. Mtuid E, Gruener G, Dockery P. Fitzgerald’s clinical neuroanatomy and neuroscience. 7th ed. Philadelphia: Elsevier; 2016.Google Scholar
  13. Neuburger M. The historical development of experimental brain and spinal cord physiology before Flourens. Baltimore: The Johns Hopkins University Press; 1981.Google Scholar
  14. Noback CR, Strominger NL, Demarest RJ, Ruggiero DA. The human nervous system: structure and function. 6th ed. Totoma: Humana Press; 2005.Google Scholar
  15. Patestas MA, Gartner LP. A text book of neuroanatomy. Oxford: Blackwell Publishing; 2006.Google Scholar
  16. Patten J. Neurological differential diagnosis. 2nd ed. London: Springer; 1996.CrossRefGoogle Scholar
  17. Snell RS. Clinical neuroanatomy. 7th ed. Philadelphia: Wolters Kluwer; 2010.Google Scholar
  18. Somers MF. Spinal cord injury. Functional rehabilitation. 3rd ed. New York: Pearson; 2010.Google Scholar
  19. Vanderah T, Gould DJ. Nolte’s the human brain. Philadelphia: Elsevier; 2016.Google Scholar
  20. Verhaagen J, McDonald JW III. Spinal cord injury. In: Aminoff MJ, Boller F, Swaab DF, editors. Handbook of clinical neurology, 3rd series, vol. 109. London: Elsevier; 2012.Google Scholar
  21. Watson C, Paxinos G, Kayalioglu G, editors. The spinal cord. A Christopher and Dana Foundation text and atlas. New York: Elsevier; 2009.Google Scholar
  22. Windle WF. The spinal cord and its reaction to traumatic injury. In: Bousquet WF, Palmer RF, editors. Modern pharmacology-toxicology: a series of monographs and textbooks. New York: Marcel Dekker, Inc.; 1980.Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Hyun-Yoon Ko
    • 1
  1. 1.Department of Rehabilitation MedicineRehabilitation Hospital, Pusan National University Yangsan Hospital, Pusan National University School of MedicineYangsanSouth Korea

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