Myelomeningocele, Chiari Malformation

  • Hyun-Yoon Ko


Spina bifida or spinal dysraphism refers to a congenital neural tube defect caused by failure of spine posterior arch closure. These can be classified as open, presenting an overlying skin defect with exposure of neural tissue and closed so that the neural tissue is covered by the skin. The most important defect is myelomeningocele, which accounts for more than 90% of open spinal dysraphisms and is associated with neurological defects.


  1. deSouza RM, Zador Z, Frim DM. Chiari malformation type I: related conditions. Neurol Res. 2011;33:278–84.CrossRefGoogle Scholar
  2. Dicianno BE, Kurowski BG, Yang JM, et al. Rehabilitation and medical management of the adult with spina bifida. Am J Phys Med Rehabil. 2008;87:1027–50.CrossRefGoogle Scholar
  3. Hudgins RJ, Gilreath CL. Tethered spinal cord following repair of myelomeningocele. Neurosurg Focus. 2004;16:E7.CrossRefGoogle Scholar
  4. Liptak GS, Dosa NP. Myelomeningocele. Pediatr Rev. 2010;31:443–50.CrossRefGoogle Scholar
  5. Liptak GS, El Samra A. Optimizing health care for children with spina bifida. Dev Disabil Res Rev. 2010;16:66–75.CrossRefGoogle Scholar
  6. Liptak GS, Garver K, Dosa NP. Spina bifida grown up. J Dev Behav Pediatr. 2013;34:206–15.CrossRefGoogle Scholar
  7. Roy AK, Slimack NP, Ganju A. Idiopathic syringomyelia: retrospective case series, comprehensive review, and update on management. Neurosurg Focus. 2011;31:E15.CrossRefGoogle Scholar
  8. Saletti V, Esposito S, Frittoli M, et al. Neurological pictures in paediatric Chiari I malformation. Neurol Sci. 2011;32(Suppl 3):S295–8.CrossRefGoogle Scholar
  9. Sandler AD. Children with spina bifida: key clinical issues. Pediatr Clin North Am. 2010;57:879–92.CrossRefGoogle Scholar
  10. Sekula RF Jr, Arnone GD, Crocker C, et al. The pathogenesis of Chiari I malformation and syringomyelia. Neurol Res. 2011;33:232–9.CrossRefGoogle Scholar
  11. Shaer CM, Chescheir N, Schulkin J. Myelomeningocele: a review of the epidemiology, genetics, risk factors for conception, prenatal diagnosis, and prognosis for affected individuals. Obstet Gynecol Surv. 2007;62:471–9.CrossRefGoogle Scholar
  12. Yamada S, Siddiqi J, Won DJ, Kido DK, et al. Symptomatic protocols for adult tethered cord syndrome. Neurol Res. 2004a;27:741–4.CrossRefGoogle Scholar
  13. Yamada S, Won DJ, Yamaga SM. Pathophysiology of tethered cord syndrome: correlation with symptomatology. Neurosurg Focus. 2004b;16:E6.CrossRefGoogle Scholar

Suggested Reading

  1. Afifi AK, Bergman RA. Functional neuroanatomy: text and atlas. 2nd ed. New York: Lange Medical Books/McGraw-Hill; 2005.Google Scholar
  2. Altman J, Bayer SA. Development of the human spinal cord: an interpretation based on experimental studies. 1st ed. New York: Oxford University Press; 2001.Google Scholar
  3. Crossman A, Neary D. Neuroanatomy: an illustrated colour test. 5th ed. Philadelphia: Elsevier; 2015.Google Scholar
  4. Durrant DH, True JM. Myelopathy, Radiculopathy, and peripheral entrapment syndromes. Boca Raton: CRC Press; 2002.Google Scholar
  5. Eagler GL, Cole J, Merton WL (eds) (1998) Spinal cord diseases: diagnosis and treatment. Marcel Dekker, Inc., New York.Google Scholar
  6. Felten DL, O’Banion MK, Maida MS. Netter’s atlas of neuroscience. 3rd ed. London: Elsevier; 2016.Google Scholar
  7. Flint G, Rusbridge C, editors. Syringomyelia, a disorder of CSF circulation. London: Springer; 2014.Google Scholar
  8. Hattingen E, Klein JC, Weidauer S, Vrionis F, Setzer M, editors. Diseases of the spinal cord. Heidelberg: Springer; 2015.Google Scholar
  9. Mai JK, Paxinos G, editors. The human nervous system. 3rd ed. London: Elsevier; 2011.Google Scholar
  10. Mancall E. Gray’s clinical neuroanatomy: the anatomic basis for clinical neuroscience. Philadelphia: Elsevier; 2011.Google Scholar
  11. Mtuid E, Gruener G, Dockery P. Fitzgerald’s clinical neuroanatomy and neuroscience. 7th ed. Philadelphia: Elsevier; 2016.Google Scholar
  12. Noback CR, Strominger NL, Demarest RJ, Ruggiero DA. The human nervous system: structure and function. 6th ed. Totoma: Humana Press; 2005.Google Scholar
  13. Patestas MA, Gartner LP. A text book of neuroanatomy. Oxford: Blackwell Publishing; 2006.Google Scholar
  14. Snell RS. Clinical neuroanatomy. 7th ed. Philadelphia: Wolters Kluwer; 2010.Google Scholar
  15. Somers MF. Spinal cord injury. Functional rehabilitation. 3rd ed. New York: Pearson; 2010.Google Scholar
  16. Sykes K, Yong JD. Respiratory support in intensive care. London: BMJ Books; 1999.Google Scholar
  17. Thron AK. Vascular anatomy of the spinal cord. neurological investigations and clinical syndromes. New York: Springer; 1988.CrossRefGoogle Scholar
  18. Vaccaro AR, Fehlings MG, Dvorak MF, editors. Spine and spinal cord trauma, evidence-based management. New York: Thieme Medical Publishers; 2011.Google Scholar
  19. Vanderah T, Gould DJ. Nolte’s the human brain. Philadelphia: Elsevier; 2016.Google Scholar
  20. Vogel LC, Zebracki K, Betz RR, Mulcahey MJ, editors. Spinal cord injury in the child and young adult. London: Mac Keith Press; 2014.Google Scholar
  21. Watson C, Paxinos G, Kayalioglu G, editors. The spinal cord. A Christopher and Dana Foundation Text and Atlas. New York: Elsevier; 2009.Google Scholar
  22. Weaver LC, Polosa C, editors. Autonomic dysfunction after spinal cord injury. In: progress in brain research, vol. 152. New York: Elsevier; 2006.Google Scholar
  23. Weidner N, Rupp R, Taney KE, editors. Neurological aspects of spinal cord injury. Cham: Springer; 2017.Google Scholar
  24. Wilberger JE, editor. Spinal cord injuries in children. New York: Futura Publishing Company; 1986.Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Hyun-Yoon Ko
    • 1
  1. 1.Department of Rehabilitation MedicineRehabilitation Hospital, Pusan National University Yangsan Hospital, Pusan National University School of MedicineYangsanSouth Korea

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