Symptom development in advanced castration-resistant prostate cancer (CRPC) patients can be attributed to local invasion of the tumor, metastasis to the bone, or compression of the spinal cord. Along the course of disease progression, 50–70% of the patients will eventually develop complications. Bone metastasis and consequent skeletal complications are the most common manifestations which may increase the risk of death from prostate cancer and decrease life quality. The clinical manifestations of bone metastasis include pain, skeletal-related events, and additional medical cost. Advancements in the understanding of the disease have resulted in the development of new palliation strategies. In this chapter, we examine several interventional options for local and systemic disease manifestation, bone-targeted palliative agents, and bone-targeted agents which potentially improve survival and management strategies for spinal cord compression. These treatments include various agents, namely, bisphosphonates, human monoclonal antibodies, and alpha- and beta-emitting radiopharmaceuticals.
Palliative care Prostatic neoplasms Castration-resistant Neoplasm metastasis
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