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Alginate Processing Routes to Fabricate Bioinspired Platforms for Tissue Engineering and Drug Delivery

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Alginates and Their Biomedical Applications

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 11))

Abstract

Alginate is a water-soluble polymer which has gained much attention in the last 20 years as suitable biomaterial for numerous applications in biomedical science and engineering. The strong biocompatibility in cell microenvironment and the possibility to process alginate solution by safe conditions to reach a stable form after polymer gelation – via ionic, chemical, or thermal route – make them useful to design different types of devices (i.e., injectable gels, porous scaffolds, micro-/nanoparticles) which are attractive for wound healing, cell transplantation, drug delivery, and three-dimensional scaffolds for tissue engineering applications.

In this chapter, current potential applications of alginates in biomedical science, tissue engineering, and drug delivery will be discussed. After a brief overview of general properties of polymer and its hydrogels, we will focus on the processing techniques mainly used for their manufacturing, also suggesting, in the last part, potential uses and future perspectives for their novel applications in biomedical field.

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Acknowledgments

This study was financially supported by the Ministero dell’Universita’ e della Ricerca through the funds of POLIFARMA (PON02 3203241) and the National Operative Program REPAIR (PON01-02342).

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Authors and Affiliations

  1. Institute for Polymers, Composites and Biomaterials, Department of Chemical Sciences & Materials Technology, National Research Council of Italy, Naples, Italy

    Vincenzo Guarino, Rosaria Altobelli, Francesca della Sala, Assunta Borzacchiello & Luigi Ambrosio

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  1. Vincenzo Guarino
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  2. Rosaria Altobelli
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  3. Francesca della Sala
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  4. Assunta Borzacchiello
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  5. Luigi Ambrosio
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Correspondence to Vincenzo Guarino .

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Editors and Affiliations

  1. Centre for Cell Factories and Biopolymers, Griffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland, Australia

    Bernd H.A. Rehm

  2. Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA

    M. Fata Moradali

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Guarino, V., Altobelli, R., della Sala, F., Borzacchiello, A., Ambrosio, L. (2018). Alginate Processing Routes to Fabricate Bioinspired Platforms for Tissue Engineering and Drug Delivery. In: Rehm, B., Moradali, M. (eds) Alginates and Their Biomedical Applications. Springer Series in Biomaterials Science and Engineering, vol 11. Springer, Singapore. https://doi.org/10.1007/978-981-10-6910-9_4

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