Genistein and Its Role in Regulation of AP-1 in Colorectal Cancer

  • Neha Merchant
  • Ganji Lakshmi Vara Prasad
  • Ganji Purnachandra Nagaraju
Chapter

Abstract

Colorectal cancer (CRC) is a prominent source of cancer-related deaths across the world. AP-1 is involved in CRC growth and metastasis. AP-1 is a transcription factor that regulates many oncogenic transduction pathways. In the current chapter, we discuss the importance of AP-1 on CRC growth and metastasis. Additionally, we discuss the mechanism of genistein, a tyrosine kinase inhibitor, and its effect on CRC treatment.

Keywords

Genistein Colorectal cancer (CRC) Activator protein-1 (AP-1) 

References

  1. 1.
    Chen J, Lin C, Yong W, Ye Y, Huang Z (2015) Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells. Cell Physiol Biochem 35:722–728CrossRefPubMedGoogle Scholar
  2. 2.
    Yan GR, Xiao CL, He GW et al (2010) Global phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways. Proteomics 10:976–986PubMedGoogle Scholar
  3. 3.
    Chen J, Hou R, Zhang X, Ye Y, Wang Y, Tian J (2014) Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. PLoS One 9:e91245CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Danielsen SA, Eide PW, Nesbakken A, Guren T, Leithe E, Lothe RA (2015) Portrait of the PI3K/AKT pathway in colorectal cancer. Biochim Biophys Acta (BBA)-Rev Cancer 1855:104–121CrossRefGoogle Scholar
  5. 5.
    Gu S, Papadopoulou N, Nasir O et al (2011) Activation of membrane androgen receptors in colon cancer inhibits the prosurvival signals Akt/bad in vitro and in vivo and blocks migration via vinculin/actin signaling. Mol Med 17:48CrossRefPubMedGoogle Scholar
  6. 6.
    Gruca A, Krawczyk Z, Szeja W, Grynkiewicz G, Rusin A (2014) Synthetic genistein glycosides inhibiting EGFR phosphorylation enhance the effect of radiation in HCT 116 colon cancer cells. Molecules 19:18558–18573CrossRefPubMedGoogle Scholar
  7. 7.
    Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66:7–30CrossRefPubMedGoogle Scholar
  8. 8.
    Salazar R, Roepman P, Capella G et al (2010) Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer. J Clin Oncol 29:17–24CrossRefPubMedGoogle Scholar
  9. 9.
    Birt DF, Hendrich S, Wang W (2001) Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther 90:157–177CrossRefPubMedGoogle Scholar
  10. 10.
    Shimizu H, Mack TM, Ross RK, Henderson BE (1987) Cancer of the gastrointestinal tract among Japanese and White immigrants in Los Angeles County 2. J Natl Cancer Inst 78:223–228PubMedGoogle Scholar
  11. 11.
    Chung DC (2000) The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis. Gastroenterology 119:854–865CrossRefPubMedGoogle Scholar
  12. 12.
    Calland J, Adams R, DePrince K, Foley E, Powell S (2000) Genetic syndromes and genetic tests in colorectal cancer. Semin Gastrointest Dis. 2000 Oct;11(4):207–18.Google Scholar
  13. 13.
    Mann B, Gelos M, Siedow A et al (1999) Target genes of β-catenin–T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci 96:1603–1608CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (2007) The activator protein-1 transcription factor in respiratory epithelium carcinogenesis. Mol Cancer Res 5:109–120CrossRefPubMedGoogle Scholar
  15. 15.
    Yao K-S, Xanthoudakis S, Curran T, O’Dwyer PJ (1994) Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. Mol Cell Biol 14:5997–6003CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Konstantinopoulos PA, Vandoros GP, Karamouzis MV, Gkermpesi M, Sotiropoulou-Bonikou G, Papavassiliou AG (2007) EGF-R is expressed and AP-1 and NF-κ: B are activated in stromal myofibroblasts surrounding colon adenocarcinomas paralleling expression of COX-2 and VEGF. Anal Cell Pathol 29:477–482Google Scholar
  17. 17.
    Debruyne PR, Bruyneel EA, Li X, Zimber A, Gespach C, Mareel MM (2001) The role of bile acids in carcinogenesis. Mutat Res Fundam Mol Mech Mutagen 480:359–369CrossRefGoogle Scholar
  18. 18.
    Ashida R, Tominaga K, Sasaki E et al (2005) AP-1 and colorectal cancer. Inflammopharmacology 13:113–125CrossRefPubMedGoogle Scholar
  19. 19.
    Shaulian E, Karin M (2001) AP-1 in cell proliferation and survival. Oncogene 20:2390CrossRefPubMedGoogle Scholar
  20. 20.
    Sabbah M, Emami S, Redeuilh G et al (2008) Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers. Drug Resist Updat 11:123–151CrossRefPubMedGoogle Scholar
  21. 21.
    Sarkar FH, Li Y, Wang Z, Padhye S (2010) Lesson learned from nature for the development of novel anti-cancer agents: implication of isoflavone, curcumin, and their synthetic analogs. Curr Pharm Des 16:1801–1812CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Yu Z, Li W, Liu F (2004) Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett 215:159–166CrossRefPubMedGoogle Scholar
  23. 23.
    Hwang J-T, Ha J, Park OJ (2005) Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. Biochem Biophys Res Commun 332:433–440CrossRefPubMedGoogle Scholar
  24. 24.
    Shen M, Hang Chan T, Ping DQ (2012) Targeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization. Anti-Cancer Agents Med Chem (Formerly Curr Med Chem-Anti-Cancer Agents) 12:891–901Google Scholar
  25. 25.
    Banerjee S, Kong D, Azmi AS et al (2011) Retracted: restoring sensitivity to oxaliplatin by a novel approach in gemcitabine-resistant pancreatic cancer cells in vitro and in vivo. Int J Cancer 128:1240–1250CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  • Neha Merchant
    • 1
  • Ganji Lakshmi Vara Prasad
    • 2
  • Ganji Purnachandra Nagaraju
    • 1
  1. 1.Department of Hematology and Medical Oncology, Winship Cancer InstituteEmory UniversityAtlantaUSA
  2. 2.Dr. LV Prasad Diagnostics and Research LaboratoryHyderabad-04APIndia

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