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Curcumin and Genistein Role in Regulation of STAT-3 in Pancreatic Cancer

  • Balney Rajitha
  • Ganji Purnachandra Nagaraju
Chapter

Abstract

Pancreatic cancer (PC) is one of the most fatal malignant tumors across the world. STAT-3 is involved in PC growth and metastasis. STAT-3 is a transcription factor that regulates many oncogenic transduction pathways. In the current chapter, we discuss the importance of STAT-3 in hypoxia and hypoxia-inducible genes. Further, we also explore the inhibition of STAT-3 by phytochemicals such as curcumin and genistein.

Keywords

Signal transducer and activator of transcription Pancreatic cancer Curcumin Genistein 

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Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  1. 1.Department of Hematology and Medical Oncology, Winship Cancer InstituteEmory UniversityAtlantaUSA

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