Role of Notch Signaling in Colorectal Cancer

  • Divya Thirumalaipillai Rajendran
  • Boopathi Subramaniyan
  • Mathan Ganeshan
Chapter

Abstract

Notch signaling is a simple pathway in its mechanism and complex because it activates many genes at transcriptional level. Notch plays an imperative role in embryogenesis and progenitor/stem cell maintenance and critically preserves the balance between a cell proliferation, differentiation, and apoptosis. Mutation and deregulation of Notch will be a reason for many diseases including cancer. Aberrantly expressed Notch involves in the carcinogenesis of many cancers such as colorectal cancer (CRC), breast cancer, pancreatic cancer, prostate cancer, liver cancer, cervical cancer, Ewing sarcoma, Kaposi’s sarcoma, lung cancer, ovarian cancer, and lymphoma. Among these, Notch plays a major role in CRC from development to metastasis. CRC occurs when the lining of colon epithelial cells becomes neoplasm, and this happens when the poise is missing between the normal and cancerous condition due to the overexpression of Notch. In CRC Notch promotes the stemness and epithelial to mesenchymal transition (EMT) which are requiring in aberrant crypt formation, invasion, and metastasis, respectively. Moreover, overexpression of Notch in CRC is connected with poor prognosis and chemoresistance. Notch counteracts with Hippo/YAP, WNT, NFkB, PI3K/Akt, and EGFR pathways for tumor initiation and development. Tumors are dependent on angiogenic switch for development and invasion which is activated by Notch ligand Dll-4 by overexpressing vascular endothelial growth factor (VEGF). This review will be focusing on the uniqueness of Notch in CRC.

Keywords

Notch CRC Chemoresistance Transcription factor and EMT pathway 

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Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  • Divya Thirumalaipillai Rajendran
    • 1
  • Boopathi Subramaniyan
    • 1
  • Mathan Ganeshan
    • 1
  1. 1.Department of Biomedical ScienceBharathidasan UniversityTiruchirappalliIndia

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