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Proteolytic Networks at the Crossroads of Cancer Cell Life and Death: Cancer Stem Cell Deciding Cell Fate

  • Poulami Khan
  • Shruti Banerjee
  • Apoorva Bhattacharya
  • Dipanwita Dutta Chowdhury
  • Apratim Dutta
  • Tanya Das
Chapter

Abstract

Over the years, proteases have been implicated in the development of tumors. The proteolytic network, which critically modulates the functioning of a normal cell, is often dysregulated in cancers. In the recent past, the identification of a subpopulation of cancer cells, termed as cancer stem cells (CSCs), has helped gain a better understanding of the complex mechanisms involved in cancer development, progression, as well as recurrence. In this context, it is of considerable importance to comprehend the pivotal role of proteases in regulating the fate of cancer cells via the CSCs. In fact, the proteolytic network influences cancer cell’s fate via CSC and its associated niche, which coordinates the functions of CSCs. In this chapter, we have emphasized on the dynamic role displayed by the proteases in regulating numerous steps of tumorigenesis commencing from tumor initiation, angiogenesis, invasion and metastasis. Apart from this, CSCs also execute a survival mechanism with the help of proteases, upon induction of apoptosis. We have also revisited the mechanisms underlying the contribution of proteases in tumor drug resistance, which ultimately leads to cancer relapse, and the role of CSCs in the same. Similarly, proteases are also intricately involved in inflammation and immune surveillance of CSCs. Given the important role of proteases in carcinogenesis, further development of antiprotease therapeutics may enable better treatment procedures and minimize the risk of recurrence. This chapter has, therefore, epitomized the complex crosstalk involving proteases, CSCs and its niche.

Keywords

Angiogenesis Cancer stem cells Drug resistance Immune surveillance Metastasis Microenvironment Proteases 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Poulami Khan
    • 1
  • Shruti Banerjee
    • 1
  • Apoorva Bhattacharya
    • 1
  • Dipanwita Dutta Chowdhury
    • 1
  • Apratim Dutta
    • 1
  • Tanya Das
    • 1
  1. 1.Division of Molecular MedicineBose InstituteKolkataIndia

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