Hydrogels pp 315-337 | Cite as

Injectable Hydrogels for Cartilage Regeneration

  • Cenk Celik
  • Vishal T. Mogal
  • James Hoi Po Hui
  • Xian Jun Loh
  • Wei Seong TohEmail author
Part of the Gels Horizons: From Science to Smart Materials book series (GHFSSM)


Articular cartilage injuries have a limited potential to heal, which over time, may lead to osteoarthritis, an inflammatory and degenerative joint disease associated with activity-related pain, swelling, and impaired mobility. Regeneration and restoration of joint tissue and function remain unmet challenges. Intra-articular injections of therapeutic agents are effective to some extent, but often require multiple injections. In the past decade, injectable hydrogels have emerged as promising biomaterials, due largely to their biocompatibility, tissue extracellular matrix (ECM) mimicry, excellent permeability, and easy adaptation for minimal-invasive procedures. Moreover, hydrogels can be designed as carriers for sustained release of therapeutic agents and protective matrices for cell delivery. This chapter provides an overview of the injectable hydrogel systems currently being applied together with therapeutic drug delivery and/or cell therapy for treatment of cartilage lesions and osteoarthritis.


Hydrogels Stem cells Drug delivery Tissue regeneration 



This work was supported by National University of Singapore, National University Healthcare System, Ministry of Education, and Agency for Science Technology and Research (A*STAR), Singapore.


The author indicates no potential conflict of interest.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Cenk Celik
    • 1
  • Vishal T. Mogal
    • 2
  • James Hoi Po Hui
    • 3
    • 4
  • Xian Jun Loh
    • 5
    • 6
    • 7
  • Wei Seong Toh
    • 2
    • 4
    Email author
  1. 1.Department of Orthopaedic Surgery, Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore
  2. 2.Faculty of DentistryNational University of SingaporeSingaporeSingapore
  3. 3.Cartilage Repair Program, Therapeutic Tissue Engineering LaboratoryNational University Health SystemSingaporeSingapore
  4. 4.Tissue Engineering Program, Life Sciences InstituteNational University of SingaporeSingaporeSingapore
  5. 5.Institute of Materials Research and Engineering (IMRE)SingaporeSingapore
  6. 6.Department of Materials Science and EngineeringNational University of SingaporeSingaporeSingapore
  7. 7.Singapore Eye Research InstituteSingaporeSingapore

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