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TLR Agonists as Adjuvants for Cancer Vaccines

  • Ji-Kun Li
  • Jesse J. Balic
  • Liang Yu
  • Brendan Jenkins
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1024)

Abstract

Toll-like receptors (TLRs) are one of the best characterised families of pattern recognition receptors (PRRs) and play a critical role in the host defence to infection. Accumulating evidence indicates that TLRs also participate in maintaining tissue homeostasis by controlling inflammation and tissue repair, as well as promoting antitumour effects via activation and modulation of adaptive immune responses. TLR agonists have successfully been exploited to ameliorate the efficacy of various cancer therapies. In this chapter, we will discuss the rationales of using TLR agonists as adjuvants to cancer treatments and summarise the recent findings of preclinical and clinical studies of TLR agonist-based cancer therapies.

Keywords

Toll-like receptor Agonist Adjuvant Clinical trial 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Ji-Kun Li
    • 1
  • Jesse J. Balic
    • 2
    • 3
  • Liang Yu
    • 1
    • 2
    • 3
  • Brendan Jenkins
    • 2
    • 3
  1. 1.Department of General Surgery, Shanghai Jiao Tong University Affiliated First People’s HospitalShanghai Jiao Tong UniversityShanghaiChina
  2. 2.Centre for Innate Immunity and Infectious DiseasesHudson Institute of Medical ResearchClaytonAustralia
  3. 3.Department of Molecular Translational Science, Faculty of Medicine, Nursing and Health SciencesMonash UniversityClaytonAustralia

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