Developmental Origins of Nonalcoholic Fatty Liver Disease (NAFLD)

  • Hiroaki ItohEmail author
  • Naohiro Kanayama
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1012)


Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Its prevalence is currently increasing not only in developed obese countries but also in developing countries. Recent findings from human cohorts and animal studies suggest that a nutritional imbalance in the early critical period is causatively associated with the incidence of NAFLD in later life. Based on the current theory of the developmental origins of health and disease (DOHaD), undernourishment and overnourishment in utero are both hypothesized to prime the predisposition for hepatic fat storage. Current knowledge on the developmental origins of NAFLD is introduced in this chapter.


Metabolic syndrome Birth weight Obesity Nutrition Pregnancy Developmental origins of health and disease (DOHaD) Fatty liver 



This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Culture and Sports, Japan (No 15H04882, No.16 K15703).


We have no conflict of interest.


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyHamamatsu University School of MedicineHigashi-ku, HamamatsuJapan

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