Urine Cytology and Emerging Biomarkers

  • Jungyo Suh


About 70% of bladder cancer diagnosis has non-muscle invasive character; however, 31–78% of them experiences recurrence and 1–45% of them progression within 5 years. For this reason, close monitoring for early detection of recurrence is essential in following up of NMIBC patients. Current gold standard for surveillance of NMIBC is based on visual inspection through cystoscopy and concurrent urine cytology examination. Urine cytology offers high specificity (83–99%) and sensitivity (84%) in high-grade lesion of UCC; however it affords only 16% of sensitivity for low-grade lesion. To overcome this limitation of urine cytology, many novel urine-based biomarkers have been developed, and some of them successfully settle on clinical practice. NMP22 (nuclear matrix protein 22), BTA (bladder tumor antigen), FDP (fibrin/fibrinogen degradation products), UroVysion (FISH), and ImmunoCyt are currently FDA (Food and Drug Administration)-approved biomarkers for detection of UCC in bladder. Most of these novel biomarkers show higher sensitivity but lower specificity than conventional urine cytology. Thus, a study for finding another useful marker and improving shortcoming of currently available biomarkers is actively on progress.


Urine cytology The Paris system for reporting urothelial malignancy Biomarker Urothelial carcinoma 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Jungyo Suh
    • 1
  1. 1.Department of UrologySeoul National University HospitalSeoulSouth Korea

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