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Immunomodulation and Photocarcinogenesis

  • Neeraj Agarwal
Chapter

Abstract

Ultraviolet radiation exposure has many biological effects, and immunosuppression is one of the least understood. UVR-suppressed immune reactions have been known for decades, and it diverges from drug-induced immunosuppression in many ways. Repeated exposure to lower doses of UVR induces long-term immunosuppression; UVR-mediated immunosuppression is antigen-specific and primarily perturbs the T-cell-driven immune reactions. UVR-induced immunosuppression is one of the factors for photocarcinogenesis.

Keywords

UV radiation Immunosuppression Skin immune system Immunotherapy 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Neeraj Agarwal
    • 1
  1. 1.Urology Division, Department of Surgery, Anschutz Medical CampusUniversity of Colorado DenverAuroraUSA

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