The Influence of Pharmacological Autonomic Blockades on Multi-Scale Measures of Heart Rate Variability

  • Faezeh Marzbanrad
  • Chandan K. Karmakar
  • Ahsan H. Khandoker
  • Marimuthu Palaniswami
  • Toshio Moritani
  • Herbert F. Jelinek
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 65)


Multi-scale measures have been used extensively to characterize non-linear dynamics of heart beats. However a physiological interpretation of the exponents associated with various scales of these measures and the role of the sympathetic and parasympathetic activities have not been attempted. In this study three multi-scale measures were compared at different scales in a pharmacological autonomic blockade experiment, starting with a control phase. It was then followed by injection of propranolol causing sympathetic blockade and injection of atropine resulting in the blockade of both sympathetic and parasympathetic pathways. Multiscale Entropy (MSE), Multi Fractal Detrended Fluctuation Analysis (MFDFA) and Renyi Entropy (RE) were compared using a paired test statistics. The measures performed differently depending on the scale factors and RE showed the best results indicating a good discrimination particularly at higher scale exponents. This study provides a basis for understanding the effect of autonomic activity on multiscale measures with respect to changes in parasympathetic and sympathetic activity.


Autonomic Blockades Autonomic Nervous System Heart Rate Variability Multi-Scale Entropy 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Faezeh Marzbanrad
    • 1
  • Chandan K. Karmakar
    • 3
  • Ahsan H. Khandoker
    • 4
  • Marimuthu Palaniswami
    • 5
  • Toshio Moritani
    • 6
  • Herbert F. Jelinek
    • 2
  1. 1.Department of Electrical and Computer Systems EngineeringMonash UniversityClaytonAustralia
  2. 2.Centre for Research in Complex Systems and School of Community HealthCharles Sturt UniversityAlburyAustralia
  3. 3.Centre of Pattern Recognition and Data AnalyticsDeakin UniversityGeelongAustralia
  4. 4.Khalifa University of ScienceTechnology and ResearchAbu DhabiUAE
  5. 5.The University of MelbourneParkvilleAustralia
  6. 6.Kyoto UniversityKyotoJapan

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