Duodenal polyps are found quite often in the routine upper endoscopies. Although inflammatory polyps are the most common entity, other lesions such as Brunner’s gland hyperplasia, gastrointestinal stromal tumor, neuroendocrine tumor, and ectopic pancreas can be seen as elevated lesions. Malignant tumors of the duodenum are uncommon. Most malignant duodenal tumors are adenocarcinomas and lymphomas. Pain, obstruction, bleeding, jaundice, and an abdominal mass are the usual symptoms and signs. Duodenal adenocarcinomas in the third and fourth portions of the duodenum are often missed on the routine upper endoscopy. High index of suspicion is very important.
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